Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
Residential exposure to magnetic fields and acute lymphoblastic leukemia in children
epidem.
[Magnetfeld-Exposition des Wohnumfeldes und akute lymphoblastische Leukämie bei Kindern]
Von:
Linet MS, Hatch EE, Kleinerman RA, Robison LL, Kaune WT, Friedman DR, Severson RK, Haines CM, Hartsock CT, Niwa S, Wacholder S, Tarone RE
Veröffentlicht in: N Engl J Med 1997; 337 (1): 1-7
Ziel der Studie (lt. Autor)
Weitere Details
Die Magnetfeld-Exposition wurde durch 24-Stunden-Messung sowie durch Berechnung der Wire-Code-Kategorien nach der Wertheimer-Leeper-Einteilung und der Kaune-Savitz-Einteilung ermittelt.
Endpunkt/Art der Risikoabschätzung
Art der Abschätzung:
(Odds Ratio (OR))
Exposition
Abschätzung
- Wire Code: basierend auf der Entfernung der Wohnung zu jeglicher Hochspannungsfreileitung in 45 m wurde die Wohnung einer der fünf Wertheimer-Leeper-Kategorien und einer der drei Kategorien des modifizierten Kaune-Savietz-Schemas zugeordnet
- Messung: 24-Stunden-Messung im Kinderzimmer; 30-Sekunden-Messungen mitten im Kinderzimmer, Wohnzimmer, Küche, Schlafzimmer der Mutter während der Schwangerschaft und im Freien 0,9 m von der Eingangstür entfernt
- Berechnung: Gesamt-Magnetfeld aus dem zeitgewichtetem Mittelwert der Raum-Messungen
Expositionsgruppen
Gruppe
|
Charakteristik
|
Referenzgruppe 1
|
Niedrigstrom
|
Gruppe 2
|
zeitgewichteter Mittelwert der Magnetfelder: 0,065 - 0,099 µT
|
Gruppe 3
|
zeitgewichteter Mittelwert der Magnetfelder: 0,100 - 0,199 µT
|
Gruppe 4
|
zeitgewichteter Mittelwert der Magnetfelder: ≥ 0,200 µT
|
Gruppe 5
|
zeitgewichteter Mittelwert der Magnetfelder: 0,200 - 0,299 µT
|
Gruppe 6
|
zeitgewichteter Mittelwert der Magnetfelder: 0,300 - 0,399 µT
|
Gruppe 7
|
zeitgewichteter Mittelwert der Magnetfelder: 0,400 - 0,499 µT
|
Gruppe 8
|
zeitgewichteter Mittelwert der Magnetfelder: ≥ 0,500 µT
|
Referenzgruppe 9
|
Wertheimer-Leeper: in der Erde verlegte Leitungen + geringe Niederstrom-Konfiguration
|
Gruppe 10
|
Wertheimer-Leeper: normale Niederstrom-Konfiguration
|
Gruppe 11
|
Wertheimer-Leeper: normale Hochstrom-Konfiguration
|
Gruppe 12
|
Wertheimer-Leeper: starke Hochstrom-Konfiguration
|
Referenzgruppe 13
|
Kaune-Savitz: niedriger Wire-Code
|
Gruppe 14
|
Kaune-Savitz: mittlerer Wire-Code
|
Gruppe 15
|
Kaune-Savitz: hoher Wire-Code
|
Population
-
Gruppe:
-
Alter:
0–14 Jahre
-
Beobachtungszeitraum:
1989 - 1994
-
Studienort:
USA (Illinios, Indiana, Iowa, Michigan, Minnesota, New Jersey, Ohio, Pennsylvania, Wisconsin)
Fallgruppe
Kontrollgruppe
- ausgewählt durch zufälliges Wählen von Telefonnummern
-
Matching:
Studiengröße
|
Fälle |
Kontrollen |
Anzahl geeignet |
1.914 |
1.987 |
Teilnehmerzahl |
767 |
725 |
Anzahl auswertbar |
638 |
620 |
Sonstiges:
Wire-Code-Kategorien für 416 Fälle und 416 Kontrollen
Statistische Analysemethode:
(
Anpassung:
- Alter
- Geschlecht
- sozioökonomischer Status
)
Ergebnisse (lt. Autor)
Studie gefördert durch
-
Children's Cancer Research Fund (at Cancer Center of University of Minnesota), USA
-
National Cancer Institute (NCI; U.S. National Institutes of Health), Maryland, USA
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