Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
A pooled analysis of magnetic fields and childhood leukaemia
epidem.
[Gepoolte Analyse zu magnetischen Feldern und Leukämie im Kindesalter]
Von:
Ahlbom A, Day N, Feychting M, Roman E, Skinner J, Dockerty J, Linet M, McBride M, Michaelis J, Olsen J, Tynes T, Verkasalo PK
Veröffentlicht in: Br J Cancer 2000; 83 (5): 692-698
Ziel der Studie (lt. Autor)
Es wurde der Zusammenhang zwischen der Exposition bei magnetischen Feldern von 50-60 Hz und Leukämie im Kindesalter untersucht. Dazu wurde eine gepoolte Analyse durchgeführt, die auf den Rohdaten aus 9 Studien basiert, die in Kanada (McBride et al.), Dänemark (Olsen et al.), Finnland (Verkasalo et al.), Deutschland (Michaelis et al. ), Neuseeland (Dockerty et al.), Norwegen (Tynes et al.), Schweden (Feychting et al.), USA (Linet et al.) und Großbritannien (UK Childhood Cancer Study Investigators) durchgeführt wurden.
Zweitens sollte analysiert werden, ob die Korrektur für bestimmte Confounder (sozioökomischer Status, Mobilität, Grad der Verstädterung, Reihenhaus/freistehendes Haus und der Höhe der Verkehrsabgase) die Ergebnisse verändern.
Drittens sollte mit Hilfe der kombinierten Daten das so genannte Wire-Code-Paradoxon (ein stärkerer Zusammenhang zwischen Ersatzmessungen der magnetischen Felder und Krebs als zwischen direkten Messungen und Krebs) untersucht werden.
Weitere Details
Es wurden alle neueren Studien berücksichtigt, in denen die Exposition durch 24-stündige bzw. 48-stündige Magnetfeld-Messungen oder mit Hilfe von berechneten Magnetfeldern geschätzt wurde. Für jeden Fall (entsprechend auch für die Kontrollen) wurde die durchschnittliche Exposition im Jahr vor der Diagnose auf der Grundlage der Rohdaten berechnet, um möglichst konsistente Daten aus allen Studien zu erhalten.
Endpunkt/Art der Risikoabschätzung
Art der Abschätzung:
(relatives Risiko (RR))
Exposition
Abschätzung
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Gruppe 1
|
geometrischer Mittelwert der gemessenen magnetischen Felder: < 0,1 µT
|
|
Gruppe 2
|
geometrischer Mittelwert der gemessenen magnetischen Felder: 0,1 - 0,2 µT
|
|
Gruppe 3
|
geometrischer Mittelwert der gemessenen magnetischen Felder: 0,2 - 0,4 µT
|
|
Gruppe 4
|
geometrischer Mittelwert der gemessenen magnetischen Felder: ≥ 0,4 µT
|
|
Gruppe 5
|
berechnete magnetische Felder: < 0,1 µT
|
|
Gruppe 6
|
berechnete magnetische Felder: 0,1 - 0,2 µT
|
|
Gruppe 7
|
berechnete magnetische Felder: 0,2 - 0,4 µT
|
|
Gruppe 8
|
berechnete magnetische Felder: ≥ 0,4 µT
|
|
Gruppe 9
|
gemessene und berechnete magnetische Felder: < 0,1 µT
|
|
Gruppe 10
|
gemessene und berechnete magnetische Felder: 0,1 - 0,2 µT
|
|
Gruppe 11
|
gemessene und berechnete magnetische Felder: 0,2 - 0,4 µT
|
|
Gruppe 12
|
gemessene und berechnete magnetische Felder: ≥ 0,4 µT
|
|
Referenzgruppe 13
|
Wertheimer-Leeper-Konfiguration: sehr gering und unterirdische Verkabelung
|
|
Gruppe 14
|
Wertheimer-Leeper-Konfiguration: normal niedrig
|
|
Gruppe 15
|
Wertheimer-Leeper-Konfiguration: normal hoch
|
|
Gruppe 16
|
Wertheimer-Leeper-Konfiguration: sehr hoch
|
Population
-
Gruppe:
-
Alter:
0–14 Jahre
-
Merkmale:
Leukämie, im US-amerikanischen Teil nur akute lymphatische Leukämie
-
Beobachtungszeitraum:
unterschiedlich für jedes Land
-
Studienort:
Kanada, Dänemark, Finnland, Deutschland, Neuseeland, Norwegen, Schweden, USA, Großbritannien
Studiengröße
| Typ |
Wert |
| Gesamtzahl |
3.247 |
Statistische Analysemethode:
(
Anpassung:
)
Ergebnisse (lt. Autor)
Studie gefördert durch
-
European Union (EU)/European Commission
-
Swedish Medical Research Council (SMRC), Sweden
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