Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
Childhood cancer and magnetic fields from high-voltage power lines in England and Wales: a case-control study
epidem.
[Krebs im Kindesalter und Magnetfelder von Hochspannungsfreileitungen in England und Wales: eine Fall-Kontroll-Studie]
Von:
Kroll ME, Swanson J, Vincent TJ, Draper GJ
Veröffentlicht in: Br J Cancer 2010; 103 (7): 1122-1127
Ziel der Studie (lt. Autor)
Endpunkt/Art der Risikoabschätzung
Art der Abschätzung:
(relatives Risiko (RR))
Exposition
Abschätzung
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Referenzgruppe 1
|
geschätzte Magnetfeldstärke an der Wohnadresse bei Geburt: < 0,1 µT
|
|
Gruppe 2
|
geschätzte Magnetfeldstärke an der Wohnadresse bei Geburt: 0,1 - < 0,2 µT
|
|
Gruppe 3
|
geschätzte Magnetfeldstärke an der Wohnadresse bei Geburt: 0,2 - < 0,4 µT
|
|
Gruppe 4
|
geschätzte Magnetfeldstärke an der Wohnadresse bei Geburt: < 0,4 µT
|
Population
-
Gruppe:
-
Alter:
0–14 Jahre
-
Beobachtungszeitraum:
1962-1995
-
Studienort:
Großbritannien (England, Wales)
Fallgruppe
Kontrollgruppe
-
Auswahl:
-
Matching:
- Geschlecht
- Geburtsdatum innerhalb von 6 Monaten, Geburtsregisterbezirk
- Fall:Kontrolle = 1:1
Studiengröße
|
Fälle |
Kontrollen |
| Anzahl geeignet |
31.273 |
- |
| Anzahl auswertbar |
28.968 |
28.968 |
Statistische Analysemethode:
- konditionale logistische Regression
Ergebnisse (lt. Autor)
Die berechneten Magnetfelder von 57704 der insgesamt 58162 Wohnungen lagen unter 0,1 µT.
Das geschätzte relative Risiko für den Anstieg von jeweils 0,2 µT betrug 1,14 für Leukämie (KI 0,57-2,32; 8 Fälle und 6 Kontrollen), 0,80 für ZNS-/Hirntumore (KI 0,43-1,51; 4 Fälle und 7 Kontrollen) und 1,34 für andere Krebs-Arten (KI 0,84-2,15; 11 Fälle und 9 Kontrollen).
Obwohl statistisch nicht signifikant, unterstützen die Ergebnisse den bestehenden Hinweis auf einen Zusammenhang zwischen der Exposition bei Magnetfeldern von Hochspannungsfreileitungen und Kinder-Leukämie. Jedoch ist es extrem unwahrscheinlich, dass die Exposition bei Magnetfeldern im Geburtsjahr der vollständige Grund für den offensichtlichen Anstieg von Kinder-Leukämie ist, der in der früheren Studie mit der Expositionsabschätzung über den Abstand der Wohnadresse bei Geburt zu den Hochspannungsfreileitungen beobachtet wurde. Die Autoren betonen, dass nur sehr wenige Wohnungen in Großbritannien bei hohen Magnetfeldstärken von Hochspannungsfreileitungen exponiert sind. Wenn Kausilität angenommen wird, liegt das geschätzte, den Magnetfeldern zugeschriebene Risiko (attributables Risiko) unter einem Fall mit Kinder-Leukämie pro Jahr.
Studie gefördert durch
-
Department of Health, UK
-
Scottish Executive/Scottish Ministers, UK
-
United Kingdom Department of Health Radiation Protection Programme
Kommentare zu diesem Artikel
-
Schmiedel S et al.
(2010):
The association between extremely low-frequency electromagnetic fields and childhood leukaemia in epidemiology: enough is enough?
Themenverwandte Artikel
-
Amoon AT et al.
(2022):
Pooled analysis of recent studies of magnetic fields and childhood leukemia
-
Núñez-Enríquez JC et al.
(2020):
Extremely Low-Frequency Magnetic Fields and the Risk of Childhood B-Lineage Acute Lymphoblastic Leukemia in a City With High Incidence of Leukemia and Elevated Exposure to ELF Magnetic Fields
-
Crespi CM et al.
(2019):
Childhood leukemia risk in the California Power Line Study: Magnetic fields versus distance from power lines
-
Swanson J et al.
(2019):
Changes over time in the reported risk for childhood leukaemia and magnetic fields
-
Kheifets L et al.
(2017):
Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California
-
Bunch KJ et al.
(2016):
Epidemiological study of power lines and childhood cancer in the UK: further analyses
-
Crespi CM et al.
(2016):
Childhood leukaemia and distance from power lines in California: a population-based case-control study
-
Zhang Y et al.
(2016):
Meta-analysis of extremely low frequency electromagnetic fields and cancer risk: a pooled analysis of epidemiologic studies
-
Leitgeb N
(2015):
Synoptic Analysis Clarifies Childhood Leukemia Risk from ELF Magnetic Field Exposure
-
Tabrizi MM et al.
(2015):
Role of electromagnetic field exposure in childhood acute lymphoblastic leukemia and no impact of urinary alpha-amylase - a case control study in Tehran, Iran
-
Pedersen C et al.
(2015):
Residential exposure to extremely low-frequency magnetic fields and risk of childhood leukaemia, CNS tumour and lymphoma in Denmark
-
Tabrizi MM et al.
(2015):
Increased risk of childhood acute lymphoblastic leukemia (ALL) by prenatal and postnatal exposure to high voltage power lines: a case control study in Isfahan, Iran
-
Salvan A et al.
(2015):
Childhood Leukemia and 50 Hz Magnetic Fields: Findings from the Italian SETIL Case-Control Study
-
Zhao L et al.
(2014):
Magnetic fields exposure and childhood leukemia risk: a meta-analysis based on 11,699 cases and 13,194 controls
-
Pedersen C et al.
(2014):
Distance from residence to power line and risk of childhood leukemia: a population-based case-control study in Denmark
-
Ba Hakim AS et al.
(2014):
ELF-EMF correlation study on distance from overhead transmission lines and acute leukemia among children in Klang Valley, Malaysia
-
Bunch KJ et al.
(2014):
Residential distance at birth from overhead high-voltage powerlines: childhood cancer risk in Britain 1962-2008
-
Swanson J et al.
(2014):
Childhood cancer and exposure to corona ions from power lines: an epidemiological test
-
Sermage-Faure C et al.
(2013):
Childhood leukaemia close to high-voltage power lines--the Geocap study, 2002-2007
-
Schüz J et al.
(2012):
Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia: an international follow-up study
-
Jirik V et al.
(2012):
Association between Childhood Leukaemia and Exposure to Power-frequency Magnetic Fields in Middle Europe
-
Swanson J et al.
(2012):
Could the geomagnetic field be an effect modifier for studies of power-frequency magnetic fields and childhood leukaemia?
-
Wünsch Filho V et al.
(2011):
Exposure to magnetic fields and childhood acute lymphocytic leukemia in Sao Paulo, Brazil
-
Malagoli C et al.
(2010):
Risk of hematological malignancies associated with magnetic fields exposure from power lines: a case-control study in two municipalities of northern Italy
-
Sohrabi MR et al.
(2010):
Living near overhead high voltage transmission power lines as a risk factor for childhood acute lymphoblastic leukemia: a case-control study
-
Kheifets L et al.
(2010):
Pooled analysis of recent studies on magnetic fields and childhood leukaemia
-
Kheifets L et al.
(2010):
A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors
-
Rahman HIA et al.
(2008):
A case-control study on the association between environmental factors and the occurrence of acute leukemia among children in Klang Valley, Malaysia
-
Yang Y et al.
(2008):
Case-only study of interactions between DNA repair genes (hMLH1, APEX1, MGMT, XRCC1 and XPD) and low-frequency electromagnetic fields in childhood acute leukemia
-
Mezei G et al.
(2008):
Residential Magnetic Field Exposure and Childhood Brain Cancer: A Meta-Analysis
-
Lowenthal RM et al.
(2007):
Residential exposure to electric power transmission lines and risk of lymphoproliferative and myeloproliferative disorders: a case-control study
-
Swanson J et al.
(2006):
Power-frequency electric and magnetic fields in the light of Draper et al. 2005
-
Kabuto M et al.
(2006):
Childhood leukemia and magnetic fields in Japan: a case-control study of childhood leukemia and residential power-frequency magnetic fields in Japan
-
Draper G et al.
(2005):
Childhood cancer in relation to distance from high voltage power lines in England and Wales: a case-control study
-
Ahlbom A et al.
(2000):
A pooled analysis of magnetic fields and childhood leukaemia
-
Kleinerman RA et al.
(2000):
Are children living near high-voltage power lines at increased risk of acute lymphoblastic leukemia?
-
UK Childhood Cancer Study Investigators
(2000):
Childhood cancer and residential proximity to power lines
-
Bianchi N et al.
(2000):
Overhead electricity power lines and childhood leukemia: a registry-based, case-control study
-
Greenland S et al.
(2000):
A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Childhood Leukemia-EMF Study Group
-
UK Childhood Cancer Study Investigators
(1999):
Exposure to power-frequency magnetic fields and the risk of childhood cancer
-
Green LM et al.
(1999):
A case-control study of childhood leukemia in southern Ontario, Canada, and exposure to magnetic fields in residences
-
Angelillo IF et al.
(1999):
Residential exposure to electromagnetic fields and childhood leukaemia: a meta-analysis
-
Green LM et al.
(1999):
Childhood leukemia and personal monitoring of residential exposures to electric and magnetic fields in Ontario, Canada
-
McBride ML et al.
(1999):
Power-frequency electric and magnetic fields and risk of childhood leukemia in Canada
-
Michaelis J et al.
(1998):
Combined risk estimates for two German population-based case-control studies on residential magnetic fields and childhood acute leukemia
-
Linet MS et al.
(1997):
Residential exposure to magnetic fields and acute lymphoblastic leukemia in children
-
Tynes T et al.
(1997):
Electromagnetic Fields and Cancer in Children Residing Near Norwegian High-Voltage Power Lines
-
Michaelis J et al.
(1997):
Childhood leukemia and electromagnetic fields: results of a population-based case-control study in Germany
-
Petridou E et al.
(1997):
Electrical power lines and childhood leukemia: a study from Greece
-
Feychting M et al.
(1993):
Magnetic fields and cancer in children residing near Swedish high-voltage power lines
-
Verkasalo PK et al.
(1993):
Risk of cancer in Finnish children living close to power lines
-
Petridou E et al.
(1993):
Age of exposure to infections and risk of childhood leukaemia
-
Olsen J et al.
(1993):
Residence near high voltage facilities and risk of cancer in children
-
Myers A et al.
(1990):
Childhood cancer and overhead powerlines: a case-control study
-
Coleman MP et al.
(1989):
Leukaemia and residence near electricity transmission equipment: a case-control study
