Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
Childhood cancer in relation to distance from high voltage power lines in England and Wales: a case-control study
epidem.
[Krebs im Kindesalter im Zusammenhang zur Entfernung von Hochspannungsfreileitungen in England und Wales: eine Fall-Kontroll-Studie]
Von:
Draper G, Vincent T, Kroll ME, Swanson J
Veröffentlicht in: BMJ 2005; 330 (7503): 1290-1292
Ziel der Studie (lt. Autor)
Endpunkt/Art der Risikoabschätzung
Art der Abschätzung:
(relatives Risiko (RR))
Exposition
Abschätzung
- Berechnung: Bestimmung der kürzesten Entfernung der Wohnadresse im Geburtsjahr zu einer Hochspannungsleitung mit Hilfe eines Rasters der insgesamt 21 800 Hochspannungsmasten
Expositionsgruppen
Gruppe
|
Charakteristik
|
Gruppe 1
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 0-49 Meter
|
Gruppe 2
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 50-99 Meter
|
Gruppe 3
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 100-199 Meter
|
Gruppe 4
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 0-199 Meter
|
Gruppe 5
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 200-299 Meter
|
Gruppe 6
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 300-399 Meter
|
Gruppe 7
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 400-499 Meter
|
Gruppe 8
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 500-599 Meter
|
Gruppe 9
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: 200-599 Meter
|
Referenzgruppe 10
|
Abstand der Wohnadresse bei Geburt zur nächsten Hochspannungsleitung: ≥ 600 Meter
|
Population
-
Gruppe:
-
Alter:
0–14 Jahre
-
Beobachtungszeitraum:
1962-1995
-
Studienort:
Großbritannien (England, Wales)
Fallgruppe
-
Merkmale:
Krebs bei Kindern, die in den Jahren 1962-1995 geboren wurden
-
Datenquelle:
Nationales Kinderkrebsregister
Kontrollgruppe
-
Matching:
- Geschlecht
- Geburtsdatum innerhalb von 6 Monaten, Geburtsregisterbezirk
- Fall:Kontrolle = 1:1
Studiengröße
|
Fälle |
Kontrollen |
Anzahl geeignet |
33.000 |
- |
Anzahl auswertbar |
29.081 |
29.081 |
Statistische Analysemethode:
- konditionale logistische Regression
- Chi-Quadrat-Test
Ergebnisse (lt. Autor)
97 % der Fälle und der Kontrollen lebten zur Zeit der Geburt mehr als 600 Meter von der nächsten Hochspannungsleitung entfernt. Kinder, deren Adresse zum Zeitpunkt der Geburt weniger als 600 Meter von einer Hochspannungsleitung entfernt war, hatten ein erhöhtes Risiko für Leukämie. Für andere Kinderkrebsarten wurden keine erhöhten Risiken gefunden.
Einschränkungen (lt. Autor)
Die Ergebnisse lassen sich durch keinen biologisch akzeptablen Mechanismus erklären. Der Zusammenhang könnte auf Zufall oder Confounding beruhen.
Studie gefördert durch
-
Department of Health, UK
-
Scottish Executive/Scottish Ministers, UK
-
United Kingdom Department of Health Radiation Protection Programme
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