Studientyp:
Epidemiologische Studie
Exposure to extremely low-frequency magnetic fields and childhood cancer: A systematic review and meta-analysis
epidem.
[Exposition bei niederfrequenten Magnetfeldern und Krebs im Kindesalter: Ein systematischer Review und Meta-Analyse]
Von:
Seomun G, Lee J, Park J
Veröffentlicht in: PLoS One 2021; 16 (5): e0251628
Ziel der Studie (lt. Autor)
Weitere Details
Folgende 30 Fall-Kontroll-Studien wurden in die Meta-Analyse eingeschlossen: Savitz et al. (1988), Myers et al. (1980), London et al. (1991), Feychting et al. (1993), Olsen et al. (1993), Preston-Martin et al. (1996), Linet et al. (1997), Michaelis et al. (1997), Tynes et al. (1997), Dockerty et al. (1998), Green et al. (1999), McBride et al. (1999), UK Childhood Cancer Study Investigators (1999), Kleinerman et al. (2000), Bianchi et al. (2000), Schüz et al. (2001), Kabuto et al. (2006), Feizi et al. (2007), Kroll et al. (2010), Malagoli et al. (2010), Saito et al. (2010), Does et al. (2011), Wünsch-Filho et al. (2011), Jirik et al. (2012), Ba Hakim et al. (2014), Bunch et al. (2014), Pedersen et al. (2014), Salvan et al. (2015), Kheifets et al. (2017) und Crespi et al. (2019).
Endpunkt/Art der Risikoabschätzung
Exposition
Abschätzung
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Referenzgruppe 1
|
magnetische Feldstärke: ≤ 0,1 µT
|
|
Gruppe 2
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magnetische Feldstärke: > 0,2 µT
|
|
Gruppe 3
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magnetische Feldstärke: > 0,3 µT
|
|
Gruppe 4
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magnetische Feldstärke: > 0,4 µT
|
Population
-
Gruppe:
-
Alter:
0–19 Jahre
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Beobachtungszeitraum:
1960 - 2009
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Studienort:
UK, Deutschland, Dänemark, Schweden, Finnland, Norwegen, Italien, Neuseeland, Kanada, USA, Japan, Iran, Brasilien, Tschechische Republik, Malaysia
Studiengröße
| Typ |
Wert |
| Gesamtzahl |
186.233 |
Sonstiges:
Kinderleukämie: 45.029 Fälle und 55.376 Kontrollen; Hirntumor: 21.582 Fälle und 29.463 Kontrollen; verschiedene Arten von Krebserkrankungen im Kindesalter: 2.470 Fälle und 3.804 Kontrollen
Statistische Analysemethode:
- Random-Effects-Modell, Heterogenitäts-Test, Sensitivitätsanalyse, Funnel-Plot
Ergebnisse (lt. Autor)
Kinder, die bei niederfrequenten Magnetfeldern mit einer Stärke von 0,2 μT, 0,3 μT bzw. 0,4 μT exponiert waren, hatten ein erhöhtes Risiko für Kinderleukämie (OR 1,26, KI 1,06-1,49; OR 1,22, KI 0,93-1,61 bzw. OR 1,72, KI 1,25-2,35). Bei Hirntumoren im Kindesalter hatten Kinder, die bei 0,2 μT exponiert waren, ein vermindertes Risiko (OR 0,95, KI 0,59-1,56), und diejenigen, die bei 0,4 μT exponiert waren, hatten ein erhöhtes Risiko (OR 1,25; KI 0,93-1,61). Kinder mit einer Exposition von 0,2 μT bzw. 0,4 μT hatten ein erhöhtes Risiko für verschiedene Arten von Krebserkrankungen im Kindesalter (OR 1,10, KI 0,70-1,75 bzw. OR 2,01, KI 0,89-4,52).
Die Autoren schlussfolgerten, dass signifikante Zusammenhänge zwischen der Exposition bei niederfrequenten Magnetfeldern und Kinderleukämie beobachtet wurden. Darüber hinaus wurde auch eine mögliche Dosis-Wirkungs-Beziehung gefunden.
Studie gefördert durch
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Korea University, Seoul, Korea
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Ministry of Education, Korea
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National Research Foundation (NRF) of Korea
Themenverwandte Artikel
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Pooled analysis of recent studies of magnetic fields and childhood leukemia
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Residential exposure to electromagnetic fields during pregnancy and risk of child cancer: A longitudinal cohort study
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Childhood leukemia risk in the California Power Line Study: Magnetic fields versus distance from power lines
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Proximity to overhead power lines and childhood leukaemia: an international pooled analysis
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Childhood leukaemia and distance from power lines in California: a population-based case-control study
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Epidemiological study of power lines and childhood cancer in the UK: further analyses
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Childhood Leukemia and 50 Hz Magnetic Fields: Findings from the Italian SETIL Case-Control Study
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Residential exposure to extremely low-frequency magnetic fields and risk of childhood leukaemia, CNS tumour and lymphoma in Denmark
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