この論文は、著者らがスウェーデンで過去に行った、1997-2003年および2007-2009年にそれぞれ診断された悪性脳腫瘍患者を対象とする症例対照研究2件をプール分析した。診断時年齢はそれぞれ、20-80歳および18-75歳である。症例は1498人(参加率89%)、人口ベースで性別と年齢をマッチさせて選出された対照は3530人(参加率87%)。ばく露情報は質問紙によった。結果として、側頭葉の神経膠腫において最も高いリスク推定値を得た;携帯電話またはコードレス電話の使用開始年齢が20歳以前の人での神経膠腫のオッズ比は、使用開始年齢がそれ以降の人に比べて高かった、などを報告している。
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A pooled analysis of case-control studies on glioma and use of mobile phones and cordless phones was conducted in Sweden.
Following studies are included: The first case-control study covering the period 1997-2000 was published in the publications Hardell et al (2002) and Hardell et al (2003). The second study covering the period 2000-2003 was published in Hardell et al (2005) concerning benign brain tumors and in Hardell et al (2006) concerning malignant brain tumors. A pooled analysis of these studies is published in Hardell et al (2006). The new case-control study on brain tumors was conducted in the period 2007-2009. The results of this new study on meningioma are published in Carlberg et al (2013). The results of the pooled analysis for acoustic neuroma, 1997-2003 and 2007-2009, is available in the publication Hardell et al (2013).
グループ | 説明 |
---|---|
参照集団 1 | unexposed |
集団 2 | analog mobile phone > 1 year latency period |
集団 3 | analog mobile phone > 1- to 5-year latency period |
集団 4 | analog mobile phone > 5- to 10-year latency period |
集団 5 | analog mobile phone > 10- to 15-year latency period |
集団 6 | analog mobile phone > 15- to 20-year latency period |
集団 7 | analog mobile phone > 20- to 25- year latency period |
集団 8 | analog mobile phone > 25 year latency period |
集団 9 | digital (2G) mobile phone > 1 year latency period |
集団 10 | digital (2G) mobile phone > 1- to 5-year latency period |
集団 11 | digital (2G) mobile phone > 5- to 10-year latency period |
集団 12 | digital (2G) mobile phone > 10- to 15-year latency period |
集団 13 | digital (2G) mobile phone > 15- to 20-year latency period |
集団 14 | digital (3G) mobile phone > 1 year latency period |
集団 15 | digital (3G) mobile phone > 1- to 5-year latency period |
集団 16 | digital (3G) mobile phone > 5- to 10-year latency period |
集団 17 | analog + digital mobile phone > 1 year latency period |
集団 18 | analog + digital mobile phone > 1- to 5-year latency period |
集団 19 | analog + digital mobile phone > 5- to 10-year latency period |
集団 20 | analog + digital mobile phone > 10- to 15-year latency period |
集団 21 | analog + digital mobile phone > 15- to 20-year latency period |
集団 22 | analog + digital mobile phone > 20-to 25-year latency period |
集団 23 | analog + digital mobile phone > 25 -year latency period |
集団 24 | cordless phone > 1 year latency period |
集団 25 | cordless phone > 1- to 5-year latency period |
集団 26 | cordless phone > 5- to 10-year latency period |
集団 27 | cordless phone > 10- to 15-year latency period |
集団 28 | cordless phone > 15- to 20-year latency period |
集団 29 | cordless phone > 20- to 25-year latency period |
集団 30 | digital phone (2G, 3G and/or cordless phone) > 1 year latency period |
集団 31 | digital phone (2G, 3G and/or cordless phone) > 1- to 5-year latency period |
集団 32 | digital phone (2G, 3G and/or cordless phone) > 5- to 10-year latency period |
集団 33 | digital phone (2G, 3G and/or cordless phone) > 10- to 15-year latency period |
集団 34 | digital phone (2G, 3G and/or cordless phone) > 10- to 15-year latency period |
集団 35 | digital phone (2G, 3G and/or cordless phone) > 20- to 25- year latency period |
集団 36 | mobile phone + cordless phone > 1 year latency period |
集団 37 | mobile phone + cordless phone > 1- to 5-year latency period |
集団 38 | mobile phone + cordless phone > 5- to 10-year latency period |
集団 39 | mobile phone + cordless phone > 10- to 15-year latency period |
集団 40 | mobile phone + cordless phone > 15- to 20-year latency period |
集団 41 | mobile phone + cordless phone > 20- to 25-year latency period |
集団 42 | mobile phone + cordless phone > 20-year latency period |
症例 | 対照 | |
---|---|---|
適格者 | 1,691 | 4,038 |
参加者 | 1,498 | 3,530 |
参加率 | 89 % | 87 % |
1380 patients with glioma
Mobile phone use increased the risk of glioma (group 17: OR 1.3, CI 1.1-1.6), increasing to OR 3.0 (CI 1.7-5.2) in the > 25 year latency group. An increased risk was observed with the use of cordless phones (group 24: OR 1.4, CI 1.1-1.7), with highest risk in the >15-20 year latency group (group 28: OR 1.7, CI 1.1-2.5). The OR increased statistically significant both per 100 h of cumulative use (OR 1.011, CI 1.008-1.014), and per year of latency for mobile and cordless phone use (OR 1.032, CI 1.019-1.046). An increased risk was found for ipsilateral mobile phone use (OR 1.8, CI 1.4-2.2) and cordless phone use (OR 1.7, CI 1.3-2.1). First use of mobile before the age of 20 gave higher OR (OR 1.8, CI 1.2-2.8) for glioma than in later age groups (20-49 years: OR 1.3, CI 1.1-1.6; 50 years and older: OR 1.3, KI 1.1-1.6); similar results were observed for cordless phone use.
The authors conclude that this pooled analysis gives further support that mobile phone and cordless phone use increases the risk for glioma.
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