Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
The Intracranial Distribution of Gliomas in Relation to Exposure From Mobile Phones: Analyses From the INTERPHONE Study
epidem.
[Die intrakranielle Verteilung von Gliom in Bezug auf die Exposition von Mobiltelefonen: Analyse aus der INTERPHONE-Studie]
Von:
Grell K, Frederiksen K, Schüz J, Cardis E, Armstrong B, Siemiatycki J, Krewski DR, McBride ML, Johansen C, Auvinen A, Hours M, Blettner M, Sadetzki S, Lagorio S, Yamaguchi N, Woodward A, Tynes T, Feychting M, Fleming SJ, Swerdlow AJ, Andersen PK
Veröffentlicht in: Am J Epidemiol 2016; 184 (11): 818-828
Ziel der Studie (lt. Autor)
Weitere Details
Es wurde ein dreidimensionales Punkt-Prozess-Modell von Grell et al. (2015) für die Analyse der Tumor-Lokalisations-Daten angewendet. Diese Methode ist eine Alternative zu den bisher verwendeten epidemiologischen Studiendesigns, da die Lokalisation in die Untersuchung von Hirntumor und Mobiltelefon-Nutzung eingeschlossen wird.
Regelmäßige Nutzung eines Mobiltelefons wurde als Nutzung für mindestens einmal pro Woche während mindestens 6 Monaten definiert.
Endpunkt/Art der Risikoabschätzung
Exposition
Abschätzung
- Fragebogen: Anzahl der Anrufe mit einem Mobiltelefon, Dauer der Anrufe, Verwendung einer Freisprecheinrichtung, bevorzugte Seite des Kopfs beim Telefonieren, Zeit seit Nutzungsbeginn
- Berechnung: Gesamtdauer der Anrufe und Gesamtzahl der Anrufe
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Referenzgruppe 1
|
Dauer der Mobiltelefon-Nutzung: < 6 Jahre
|
|
Gruppe 2
|
Dauer der Mobiltelefon-Nutzung: ≥ 6 Jahre
|
|
Referenzgruppe 3
|
kumulative Mobiltelefon-Nutzung: < 200 Stunden
|
|
Gruppe 4
|
kumulative Mobiltelefon-Nutzung: ≥ 200 Stunden
|
|
Referenzgruppe 5
|
Gesamtzahl an Anrufen: < 4.000
|
|
Gruppe 6
|
Gesamtzahl an Anrufen: ≥ 4.000
|
Population
-
Gruppe:
-
Alter:
30–59 Jahre
-
Merkmale:
Gliom, histologisch bestätigt
-
Beobachtungszeitraum:
2000 - 2004
-
Studienort:
Australien, Kanada, Dänemark, Finnland, Frankreich, Deutschland, Israel, Italien, Japan, Neuseeland, Norwegen, Schweden und Großbritannien
Studiengröße
| Typ |
Wert |
| Gesamtzahl |
2.700 |
| Anzahl geeignet |
1.530 |
| Anzahl auswertbar |
792 |
Statistische Analysemethode:
Ergebnisse (lt. Autor)
Es wurde ein statistisch signifikanter Zusammenhang zwischen der intrakraniellen Verteilung von Gliomen und der selbstberichteten Position des Mobiltelefons beobachtet. Das bedeutet, dass mehr Gliome näher am Ohr auf der Kopfseite auftraten, an der das Mobiltelefon nach Angaben des Nutzers am meisten genutzt wurde. Der Zusammenhang war unabhängig von der kumulativen Nutzungsdauer und der Gesamtzahl der Anrufe. So ist es weniger wahrscheinlich, dass der beobachtete Zusammenhang durch die Nutzung eines Mobiltelefons verursacht wird.
Einschränkungen (lt. Autor)
Im Modell wurde die selbstberichtete Seite bei der Mobiltelefon-Nutzung verwendet, dies wird möglicherweise durch Recall-Bias beeinflusst.
Studie gefördert durch
-
3
-
Academy of Finland
-
Association pour la Recherche sur le Cancer (ARC), France
-
Bouygues Telecom, France
-
Canada Research Chairs (Chaires de Recherche du Canada), Ottawa, Ontario, Canada
-
Canadian Institutes of Health Research (CIHR)
-
Canadian Wireless Telecommunications Association (CWTA; Association canadienne des télécommunications sans fil (ACTS)), Canada
-
Cancer Society of New Zealand
-
Danish Cancer Society
-
Department of Health, UK
-
Deutsches Mobilfunk Forschungsprogramm (DMF; German Mobile Phone Research Programme) at Federal Office for Radiation Protection (BfS)
-
Emil Aaltonen Foundation, Finland
-
European Union (EU)/European Commission
-
GSM Association, UK/Ireland
-
Health and Safety Executive, UK
-
Health Research Council of New Zealand
-
International Union against Cancer (UICC; Union Internationale Contre le Cancer), Switzerland
-
MAIFOR Program (Mainzer Forschungsförderungsprogramm) of the University of Mainz, Germany
-
Ministerium für Umwelt und Naturschutz, Landwirtschaft und Verbraucherschutz, Nordrhein-Westfalen (Ministry for the Environment of the state of North Rhine-Westphalia), Germany
-
Ministerium für Umwelt, Klima und Energiewirtschaft, Baden-Württemberg (Ministry of the Environment, Climate Protection and the Energy Sector of the state of Baden-Württemberg), Germany
-
Ministry of Internal Affairs and Communications, Japan
-
Mobile Manufacturers Forum (MMF), Belgium
-
Mobile Telecommunications and Health Research (MTHR), UK
-
National Health and Medical Research Council (NHMRC), Australia
-
National Health Service (NHS), UK
-
Natural Sciences and Engineering Research Council (NSERC) of Canada
-
O2
-
Orange
-
Scottish Executive/Scottish Ministers, UK
-
SFR, France
-
Swedish Research Council (VR)
-
T-Mobile
-
University of Sydney, Australia
-
Vodafone
-
Waikato Medical Research Foundation (WMRF), New Zealand
-
Wellington Medical Research Foundation (WMRF), New Zealand
Themenverwandte Artikel
-
Yang M et al.
(2017):
Mobile phone use and glioma risk: A systematic review and meta-analysis
-
Wang Y et al.
(2016):
Meta-analysis of association between mobile phone use and glioma risk
-
de Vocht F
(2016):
Inferring the 1985-2014 impact of mobile phone use on selected brain cancer subtypes using Bayesian structural time series and synthetic controls
-
Sato Y et al.
(2016):
Time trend in incidence of malignant neoplasms of the central nervous system in relation to mobile phone use among young people in Japan
-
Chapman S et al.
(2016):
Has the incidence of brain cancer risen in Australia since the introduction of mobile phones 29 years ago?
-
Yoon S et al.
(2015):
Mobile phone use and risk of glioma: a case-control study in Korea for 2002-2007
-
Leitgeb N
(2015):
Synoptic Analysis of Epidemiologic Evidence of Glioma Risk from Mobile Phones
-
Carlberg M et al.
(2015):
Pooled analysis of Swedish case-control studies during 1997-2003 and 2007-2009 on meningioma risk associated with the use of mobile and cordless phones
-
Kim SJH et al.
(2015):
Trends in incidence of primary brain cancer in New Zealand, 1995 to 2010
-
Hardell L et al.
(2015):
Mobile phone and cordless phone use and the risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009
-
Lagorio S et al.
(2014):
Mobile phone use and risk of intracranial tumors: A consistency analysis
-
Coureau G et al.
(2014):
Mobile phone use and brain tumours in the CERENAT case-control study
-
Carlberg M et al.
(2014):
Decreased Survival of Glioma Patients with Astrocytoma Grade IV (Glioblastoma Multiforme) Associated with Long-Term Use of Mobile and Cordless Phones
-
Hardell L et al.
(2013):
Case-control study of the association between malignant brain tumours diagnosed between 2007 and 2009 and mobile and cordless phone use
-
Hardell L et al.
(2013):
Use of mobile and cordless phones and survival of patients with glioma
-
Benson VS et al.
(2013):
Mobile phone use and risk of brain neoplasms and other cancers: prospective study
-
Hsu MH et al.
(2013):
The incidence rate and mortality of malignant brain tumors after 10 years of intensive cell phone use in Taiwan
-
Barchana M et al.
(2012):
Changes in brain glioma incidence and laterality correlates with use of mobile phones - a nationwide population based study in Israel
-
Carlberg M et al.
(2012):
On the association between glioma, wireless phones, heredity and ionising radiation
-
Deltour I et al.
(2012):
Mobile Phone Use and Incidence of Glioma in the Nordic Countries 1979-2008: Consistency Check
-
Hardell L et al.
(2011):
Pooled analysis of case-control studies on malignant brain tumours and the use of mobile and cordless phones including living and deceased subjects
-
Ding LX et al.
(2011):
Increasing incidence of brain and nervous tumours in urban Shanghai, China, 1983-2007
-
Aydin D et al.
(2011):
Mobile phone use and brain tumors in children and adolescents: a multicenter case-control study
-
Cardis E et al.
(2011):
Risk of brain tumours in relation to estimated RF dose from mobile phones: results from five Interphone countries
-
Larjavaara S et al.
(2011):
Location of Gliomas in Relation to Mobile Telephone Use: A Case-Case and Case-Specular Analysis
-
de Vocht F et al.
(2011):
Time trends (1998-2007) in brain cancer incidence rates in relation to mobile phone use in England
-
Lehrer S et al.
(2011):
Association between number of cell phone contracts and brain tumor incidence in nineteen U.S. States
-
Inskip PD et al.
(2010):
Brain cancer incidence trends in relation to cellular telephone use in the United States
-
Hardell L et al.
(2010):
Mobile Phone Use and the Risk for Malignant Brain Tumors: A Case-Control Study on Deceased Cases and Controls
-
INTERPHONE Study Group et al.
(2010):
Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study
-
Goldwein O et al.
(2010):
The influence of handheld mobile phones on human parotid gland secretion
-
Deltour I et al.
(2009):
Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974-2003
-
Myung SK et al.
(2009):
Mobile phone use and risk of tumors: a meta-analysis
-
Hardell L et al.
(2009):
Mobile phones, cordless phones and the risk for brain tumours
-
Hardell L et al.
(2009):
Epidemiological evidence for an association between use of wireless phones and tumor diseases
-
Hartikka H et al.
(2009):
Mobile phone use and location of glioma: a case-case analysis
-
Takebayashi T et al.
(2008):
Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case-control study
-
Hardell L et al.
(2008):
Meta-analysis of long-term mobile phone use and the association with brain tumours
-
Lahkola A et al.
(2007):
Mobile phone use and risk of glioma in 5 North European countries
-
Cardis E et al.
(2007):
The INTERPHONE study: design, epidemiological methods, and description of the study population
-
Klaeboe L et al.
(2007):
Use of mobile phones in Norway and risk of intracranial tumours
-
Schüz J et al.
(2006):
Cellular telephone use and cancer risk: update of a nationwide Danish cohort
-
Lahkola A et al.
(2006):
Meta-analysis of mobile phone use and intracranial tumors
-
Vrijheid M et al.
(2006):
Validation of short term recall of mobile phone use for the Interphone study
-
Hardell L et al.
(2006):
Pooled analysis of two case-control studies on use of cellular and cordless telephones and the risk for malignant brain tumours diagnosed in 1997-2003
-
Schüz J et al.
(2006):
Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany)
-
Hepworth SJ et al.
(2006):
Mobile phone use and risk of glioma in adults: case-control study
-
Christensen HC et al.
(2005):
Cellular telephones and risk for brain tumors: a population-based, incident case-control study
-
Lönn S et al.
(2005):
Long-term mobile phone use and brain tumor risk
-
Lönn S et al.
(2004):
Incidence trends of adult primary intracerebral tumors in four Nordic countries
-
Inskip PD et al.
(2001):
Cellular-telephone use and brain tumors
-
Hardell L et al.
(1999):
Use of cellular telephones and the risk for brain tumours: A case-control study
