この研究は、超低周波磁界(ELF-MF:50 Hz、100 μT)とアルミニウム(Al)のアルツハイマー病(AD)発病への相乗効果の有無を調べた。成獣のSD雄ラットを10匹ずつの4群に分けた。対照群(擬似ばく露)、Al群(Alの経口摂取)、MF+Al群(ELF-MFばく露+Alの経口摂取)、MF単独群(ELF-MFばく露のみ)である。Al経口摂取はAl含有飲料水の自由摂取により、ELF-MFばく露はヘルムホルツコイルにより、1日24時間、12週間連続ばく露した。ばく露終了後、行動テストおよび海馬と大脳皮質の組織検査を行った。その結果、Al群、MF+Al群では、学習と記憶の障害、海馬と大脳皮質の組織での神経細胞脱落やアミロイドβ沈着が見られた;MF単独群はAD発症への有意な影響を示さなかった;Al群よりMF+Al群の方が損傷の程度が低かった、と報告している。
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To study whether or not an extremely low-frequency magnetic field exposure and aluminium treatment have synergistic effects on Alzheimer's disease pathogenesis by investigating the effects of extremely low-frequency magnetic field exposure with or without chronic aluminium treatment in rats.
Rats were divided into the following groups (each group n=10): 1.) sham exposure, 2.) oral aluminium administration, 3.) magnetic field exposure with oral aluminium administration, or 4.) magnetic field exposure without oral aluminium administration. The experiments were repeated three times.
ばく露 | パラメータ |
---|---|
ばく露1:
50 Hz
ばく露時間:
continuous for 12 weeks
|
|
Rats of the control groups were placed in a geomagnetic environment (ambient magnetic field (50 Hz) <400 nT; geomagnetic field 9-32 µT)
周波数 | 50 Hz |
---|---|
タイプ |
|
ばく露時間 | continuous for 12 weeks |
ばく露の発生源/構造 | |
---|---|
チャンバの詳細 | rats were housed in plastic cages |
ばく露装置の詳細 | pair of Helmholtz coils (diameter: 1400 mm); rats placed in the center of the coils; magnetic field direction was vertical; room temperature 23±1°C |
測定量 | 値 | 種別 | Method | Mass | 備考 |
---|---|---|---|---|---|
磁束密度 | 100 µT | - | - | - | - |
After 12 weeks, aluminium groups (groups 2 and 3) showed learning and memory impairments as well as morphological changes in the brain, including neuronal cell loss and a high density of beta-amyloid protein in the hippocampus and cerebral cortex. Extremely low-frequency magnetic exposure alone (group 4) showed no significant effect on Alzheimer's disease pathogenesis. Co-exposure of extremely low-frequency magnetic field and aluminium (group 3) did not induce more damage than aluminium treatment alone (group 2).
The data showed no evidence of any association between extremely low-frequency magnetic exposure exposure (100 µT, 50 Hz) and Alzheimer's disease, and extremely low-frequency magnetic field exposure did not influence the pathogenesis of Alzheimer's disease induced by aluminium overload.
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