本研究は、超低周波(ELF)磁界がラット脳内のベータアミロイドタンパク(BAP)、カルボニル化タンパク(PC)、マロンジアルデヒド(MDA)に及ぼす影響を調べた動物実験である。30匹の雄の成獣のSprague-Dawleyラットを2つのばく露群と偽ばく露群に分け、ばく露群はそれぞれ100、500μTの50Hz磁界に2時間/日、10か月間ばく露した。その結果、どちらのELF磁界もBAPレベルに有意に変化を生じなかった;どちらのELF磁界もPCおよびMDAレベルを増加させた、と報告している。
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To study the effects of 100 µT and 500 µT extremely low-frequency magnetic fields on levels of beta-amyloid protein, protein carbonyl and malondialdehyde in rat brain. The aim of this study was to illuminate the interaction between biomolecules and extremely low-frequency magnetic fields.
30 rats were divided into 3 groups: 2 exposure groups (100 µT and 500 µT) and 1 sham exposure group (each group n=10).
周波数 | 50 Hz |
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タイプ |
|
ばく露時間 | 2 h/day for 10 months |
ばく露の発生源/構造 | |
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チャンバの詳細 | exposures were carried out in methacrylate cages; rats moved freely in the cages during exposure |
ばく露装置の詳細 | pair of Helmholtz coils of 25 cm diameter in a Faraday cage (130 X 65 x 80 cm), with shielding grounded to protect against stray environmental electrical fields; coils were placed horizontally facing one another, and the distance between coils was 25 cm |
Sham exposure | A sham exposure was conducted. |
測定量 | 値 | 種別 | Method | Mass | 備考 |
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磁束密度 | 100 µT | spatial average | 測定値 | - | - |
Protein carbonyl group and malondialdehyde levels were significantly increased by the exposure to 100 µT and 500 µT extremely low-frequency magnetic fields. However, beta-amyloid protein level was not significantly affected. In conclusion, the data showed that long-term exposure (2 h/day for 10 months) can affect some biological macromolecules such as proteins and lipids.
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