この研究は、SD雄ラット(n=20)を用いて超低周波電磁界(ELF-EMF)ばく露と記憶障害の関係を調べた。12週齢のラットをばく露群、擬似ばく露群(それぞれn=10)に無作為に分け、100μT、50HzのELF-EMFに12週間、ばく露(擬似ばく露)した後、モーリス水迷路(MWM)により認知および記憶の能力の変化を測定し、また、大脳皮質、海馬、血漿のアミロイドβ(Aβ)含有量を測定した。その結果、ばく露群、擬似ばく露群で、ばく露終了後の体重に有意差はなかった;認知ならびに記憶の障害、またAβ含有量や組織学的変化にも両群で違いはなかった、と報告している。
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To examine the influence of exposure to extremely low frequency magnetic fields on memory impairment in rats.
Rats were exposed (n=10) or sham exposed (n=10).
At the end of the exposure period, rats were subjected to the Morris water maze. Afterwards, they were killed to remove the brain and take blood samples.
ばく露 | パラメータ |
---|---|
ばく露1:
50 Hz
ばく露時間:
continuous for 12 weeks
|
|
周波数 | 50 Hz |
---|---|
タイプ |
|
ばく露時間 | continuous for 12 weeks |
ばく露の発生源/構造 | |
---|---|
チャンバの詳細 | rats were placed in a special plastic box without metallic parts; animals were able to move freely in the box |
ばく露装置の詳細 | coil of Helmholtz with two parallel spires (5.2 m Œ 5.2 m) was used; distance between two coils was 2 m, and one was buried underground for 0.7 m |
Sham exposure | A sham exposure was conducted. |
測定量 | 値 | 種別 | Method | Mass | 備考 |
---|---|---|---|---|---|
磁束密度 | 100 µT | - | 測定値 | - | - |
No significant differences were observed in the body weight, histopathological examination of the brain, content of beta-amyloid protein, and the performance in the Morris water maze between exposed and sham exposed rats.
The results indicate that exposure to extremely low frequency magnetic fields has no influence on the memory performance of rats.
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