Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
Occupational exposure to magnetic fields and electric shocks and risk of ALS: The Swiss National Cohort
epidem.
[Berufliche Exposition bei Magnetfeldern und Stromschlägen und das Risiko für ALS: die nationale Schweizer Kohorte]
Von:
Huss A, Spoerri A, Egger M, Kromhout H, Vermeulen R
Veröffentlicht in: Amyotroph Lateral Scler Frontotemporal Degener 2015; 16 (1-2): 80-85
Ziel der Studie (lt. Autor)
Weitere Details
Endpunkt/Art der Risikoabschätzung
Exposition
Abschätzung
- Liste: Klassifizierung der Berufsbezeichnung in Elektroberufe
- Job-Exposure-Matrix: Daten zum Beruf aus den Volkszählungen von 1990 und 2000
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Referenzgruppe 1
|
Magnetfeld-Exposition (Job-Exposure-Matrix): niedrig
|
|
Gruppe 2
|
Magnetfeld-Exposition (Job-Exposure-Matrix): mittel
|
|
Gruppe 3
|
Magnetfeld-Exposition (Job-Exposure-Matrix): hoch
|
|
Referenzgruppe 4
|
Stromschläge (Job-Exposure-Matrix): niedrig
|
|
Gruppe 5
|
Stromschläge (Job-Exposure-Matrix): mittel
|
|
Gruppe 6
|
Stromschläge (Job-Exposure-Matrix): hoch
|
|
Referenzgruppe 7
|
Elektro-Berufe (nach Deapen et al., 1988): nein
|
|
Gruppe 8
|
Elektro-Berufe (nach Deapen et al., 1988): ja
|
|
Referenzgruppe 9
|
Elektro-Berufe (nach Feychting et al., 2003): nein
|
|
Gruppe 10
|
Elektro-Berufe (nach Feychting et al., 2003): ja
|
Population
-
Gruppe:
-
Alter:
≥ 30 Jahre
-
Merkmale:
Teilnehmer der nationalen Schweizer Kohorte
-
Beobachtungszeitraum:
1990 - 2008
-
Studienort:
Schweiz
-
Datenquelle:
Einwohnermeldeamt, nationale Schweizer Kohorte
-
Ausschlusskriterien:
Rentner
Studiengröße
| Typ |
Wert |
| Gesamtzahl |
2.167.046 |
Statistische Analysemethode:
- proportionale Hazard-Regression nach Cox
(
Anpassung:
)
Ergebnisse (lt. Autor)
Insgesamt starben 278 Personen der Studienpopulation an amyotropher Lateralsklerose.
Bei einer getrennten Analyse der Daten aus den Volkszählungen von 1990 und 2000 war die Mortalität an amyotropher Lateralsklerose bei Arbeitern mit Exposition bei extrem niederfrequenten Magnetfeldern, Arbeitern mit einem Risiko für Stromschlag und Arbeitern in Elektroberufen nicht erhöht. Die Mortalität war bei Arbeitern mit einer mittleren oder hohen Magnetfeld-Exposition in beiden Volkszählungen (HR 1,55; KI 1,11-2.15) erhöht, bei Arbeitern mit einem Risiko für Stromschläge (HR 1,17; KI 0.83-1.65) war die Mortalität leicht erhöht. Wenn beide Expositionen gemeinsam ausgewertet wurden, veränderte sich die Hazard-Rate für niederfrequente Magnetfelder wenig (HR 1,56; KI 1,09-2,25), jedoch war die Hazard-Rate für Stromschläge abgeschwächt (HR 0,97; KI 0.66-1,42).
Die Autoren schlussfolgerten, dass es einen Zusammenhang zwischen der Exposition bei niederfrequenten Magnetfeldern und der Mortalität von amyotropher Lateralsklerose bei Arbeitern mit einer höheren Wahrscheinlichkeit für eine Langzeit-Exposition gab.
Studie gefördert durch
-
Swiss National Science Foundation (SNF)
-
ZonMw, The Netherlands
Themenverwandte Artikel
-
Mezei G et al.
(2022):
Receipt of Electroconvulsive Therapy and Subsequent Development of Amyotrophic Lateral Sclerosis: A Cohort Study
-
Sorahan T et al.
(2022):
Motor neuron disease risk and magnetic field exposures
-
Chen GX et al.
(2021):
Associations of Occupational Exposures to Electric Shocks and Extremely Low-Frequency Magnetic Fields With Motor Neurone Disease
-
Huang LY et al.
(2020):
Association of Occupational Factors and Dementia or Cognitive Impairment: A Systematic Review and Meta-Analysis
-
Gunnarsson LG et al.
(2019):
Occupational Exposures and Neurodegenerative Diseases-A Systematic Literature Review and Meta-Analyses
-
Peters S et al.
(2019):
Associations of Electric Shock and Extremely Low-Frequency Magnetic Field Exposure With the Risk of Amyotrophic Lateral Sclerosis: The Euro-MOTOR Project
-
Gunnarsson LG et al.
(2018):
Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses
-
Huss A et al.
(2018):
Occupational exposure to extremely low-frequency magnetic fields and the risk of ALS: A systematic review and meta-analysis
-
Koeman T et al.
(2017):
Occupational exposure and amyotrophic lateral sclerosis in a prospective cohort
-
Pedersen C et al.
(2017):
Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers
-
Fischer H et al.
(2015):
Occupational Exposure to Electric Shocks and Magnetic Fields and Amyotrophic Lateral Sclerosis in Sweden
-
Huss A et al.
(2015):
Extremely Low Frequency Magnetic Field Exposure and Parkinson's Disease-A Systematic Review and Meta-Analysis of the Data
-
Koeman T et al.
(2015):
Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study
-
Brouwer M et al.
(2015):
Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort
-
van der Mark M et al.
(2015):
Extremely low-frequency magnetic field exposure, electrical shocks and risk of Parkinson's disease
-
Vergara X et al.
(2015):
Case-control study of occupational exposure to electric shocks and magnetic fields and mortality from amyotrophic lateral sclerosis in the US, 1991-1999
-
Capozzella A et al.
(2014):
Work related etiology of amyotrophic lateral sclerosis (ALS): a meta-analysis
-
Sorahan T et al.
(2014):
Neurodegenerative disease and magnetic field exposure in UK electricity supply workers
-
Vergara X et al.
(2013):
Occupational exposure to extremely low-frequency magnetic fields and neurodegenerative disease: a meta-analysis
-
Parlett LE et al.
(2011):
Evaluation of occupational exposure to magnetic fields and motor neuron disease mortality in a population-based cohort
-
Andel R et al.
(2010):
Work-related exposure to extremely low-frequency magnetic fields and dementia: results from the population-based study of dementia in Swedish twins
-
Garcia AM et al.
(2008):
Occupational exposure to extremely low frequency electric and magnetic fields and Alzheimer disease: a meta-analysis
-
Sorahan T et al.
(2007):
Mortality from Alzheimer's, motor neurone and Parkinson's disease in relation to magnetic field exposure: findings from the study of UK electricity generation and transmission workers, 1973-2004
-
Seidler A et al.
(2007):
Occupational exposure to low frequency magnetic fields and dementia: a case-control study
-
Davanipour Z et al.
(2007):
A case-control study of occupational magnetic field exposure and Alzheimer's disease: results from the California Alzheimer's Disease Diagnosis and Treatment Centers
-
Röösli M et al.
(2007):
Mortality from neurodegenerative disease and exposure to extremely low-frequency magnetic fields: 31 years of observations on Swiss railway employees
-
Hug K et al.
(2006):
Magnetic field exposure and neurodegenerative diseases--recent epidemiological studies
-
Park RM et al.
(2005):
Potential occupational risks for neurodegenerative diseases
-
Qiu C et al.
(2004):
Occupational exposure to electromagnetic fields and risk of Alzheimer's disease
-
Harmanci H et al.
(2003):
Risk factors for Alzheimer disease: a population-based case-control study in Istanbul, Turkey
-
Hakansson N et al.
(2003):
Neurodegenerative diseases in welders and other workers exposed to high levels of magnetic fields
-
Feychting M et al.
(2003):
Occupational Magnetic Field Exposure and Neurodegenerative Disease
-
Noonan CW et al.
(2002):
Occupational exposure to magnetic fields in case-referent studies of neurodegenerative diseases
-
Johansen C
(2000):
Exposure to electromagnetic fields and risk of central nervous system disease in utility workers
-
Graves AB et al.
(1999):
Occupational exposure to electromagnetic fields and Alzheimer disease
-
Savitz DA et al.
(1998):
Electrical occupations and neurodegenerative disease: analysis of U.S. mortality data
-
Feychting M et al.
(1998):
Dementia and occupational exposure to magnetic fields
-
Savitz DA et al.
(1998):
Magnetic field exposure and neurodegenerative disease mortality among electric utility workers
-
Schulte PA et al.
(1996):
Neurodegenerative diseases: occupational occurrence and potential risk factors, 1982 through 1991
-
Sobel E et al.
(1996):
Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure
-
Sobel E et al.
(1995):
Occupations with exposure to electromagnetic fields: a possible risk factor for Alzheimer's disease
-
Gunnarsson LG et al.
(1992):
A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents
