研究のタイプ:
疫学研究
(observational study)
[INTEROCC研究における超低周波磁界への職業ばく露と脳腫瘍リスク]
epidem.
Occupational exposure to extremely low frequency magnetic fields and brain tumour risks in the INTEROCC study
著者:
Turner MC, Benke G, Bowman JD, Figuerola J, Fleming S, Hours M, Kincl L, Krewski D, McLean D, Parent ME, Richardson L, Sadetzki S, Schlaefer K, Schlehofer B, Schüz J, Siemiatycki J, van Tongeren M, Cardis E
掲載誌: Cancer Epidemiol Biomarkers Prev 2014; 23 (9): 1863-1872
この研究は、大規模INTERROCC研究の一環で、超低周波磁界(ELF-MF)と脳腫瘍の関連を調べた。2000-2004年に診断された成人の原発性の神経膠腫および髄膜腫の症例を7ヵ国(オーストラリア、カナダ、フランス、ドイツ、イスラエル、ニュージーランド、英国)から集めた。就労日の平均ELF-MFばく露の推定値は職種ばく露マトリクスに拠った。累積ばく露、平均ばく露、最大ばく露、ばく露期間の推定値は、4つの期間(生涯、診断日/参照日の前の1-4、5-9、10+年間)について算出した。その結果、神経膠腫1939、髄膜腫1822の合計3761症例と人口ベースの対照5404が分析された;ELF-MFの生涯累積ばく露と神経膠腫および髄膜腫のリスクに関連は無かった;ただし、診断日/参照日の前の1-4年間の累積ばく露と神経膠腫リスクの間には正の関連があった(< 25thパーセンタイルに対する≥ 90th パーセンタイルのオッズ比(OR)は1.67;95% 信頼区間(CI)は1.36-2.07);髄膜腫の同様のORは1.23(95% CI:0.97-1.57)であった、と報告している。
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研究の目的(著者による)
The association between occupational exposure to extremely low frequency magnetic fields and brain tumor risks was investigated in an international case-control study (INTEROCC study).
詳細情報
Seven of the overall 13 countries participating in the INTERPHONE study conducted the INTEROCC study to address potential occupational risk factors for glioma and meningioma.
影響評価項目/リスク推定のタイプ
- 脳腫瘍: glioma and meningioma
ばく露
ばく露評価
- 質問票: lifetime occupational calendar for all jobs held for a minimum of 6 months, including job title, company name, company description, and start and stop year
- 職種ばく露マトリクス
- 計算: cumulative exposure, average exposure, maximum exposure, and exposure duration were calculated for the lifetime and for time periods of 1-4, 5-9 and ≥ 10 years before diagnosis date based on the job exposure matrix
ばく露集団
グループ
|
説明
|
参照集団 1
|
cumulative exposure: < 2.11 µT-years
|
集団 2
|
cumulative exposure: 2.11 - < 3.40 µT-years
|
集団 3
|
cumulative exposure: 3.40 - < 5.00 µT-years
|
集団 4
|
cumulative exposure: 5.00 - < 7.50 µT-years
|
集団 5
|
cumulative exposure: ≥ 7.50 µT-years
|
参照集団 6
|
average exposure: < 0.11 µT
|
集団 7
|
average exposure: 0.11 - < 0.13 µT
|
集団 8
|
average exposure: 0.13 - < 0.17 µT
|
集団 9
|
average exposure: 0.17 - 0.24 µT
|
集団 10
|
average exposure: ≥ 0.24 µT
|
参照集団 11
|
maximum exposed job: < 0.13 µT
|
集団 12
|
maximum exposed job: 0.13 - < 0.17 µT
|
集団 13
|
maximum exposed job: 0.17 - < 0.23 µT
|
集団 14
|
maximum exposed job: 0.23 - < 0.62 µT
|
集団 15
|
maximum exposed job: ≥ 0.62 µT
|
参照集団 16
|
exposure duration: < 5 years
|
集団 17
|
exposure duration: 5 - < 15 years
|
集団 18
|
exposure duration: 15 - < 25 years
|
集団 19
|
exposure duration: ≥ 25 years
|
調査対象集団
-
グループ:
-
年齢:
30–69年
-
観察期間:
2000 - 2004
-
調査地域:
Australia, Canada, France, Germany, Israel, New Zealand, UK
症例集団
-
特性:
patients with glioma or meningioma
-
データ源:
INTEROCC study
対照集団
調査規模
|
症例 |
対照 |
適格者 |
5,399 |
11,112 |
参加者 |
3,978 |
5,601 |
評価可能 |
3,761 |
5,404 |
その他:
1939 patients with glioma and 1822 patients with meningioma
結論(著者による)
No association between lifetime cumulative exposure to extremely low frequency magnetic fields and glioma or meningioma risk was observed. However, an association between cumulative exposure to extremely low frequency magnetic fields in the time period 1 to 4 years before the diagnosis date and glioma was observed (OR ≥ 90th percentile vs. < 25th percentile: 1.67, CI 1.36-2.07), and a statistically non-significant association with meningioma (OR 1.23, CI 0.97-1.57) was found.
The authors concluded that the results showed an association between occupational exposure to extremely low frequency magnetic fields in the recent past and glioma. Occupational exposure to extremely low frequency magnetic fields may play a role in the later stages (promotion and progression) of brain tumorigenesis.
研究助成
-
3
-
AFSSET (L'Agence française de sécurité sanitaire de l'environnement et du travail) France
-
Association pour la Recherche sur le Cancer (ARC), France
-
Australian Research Council (ARC)
-
Bouygues Telecom, France
-
Canada Research Chairs (Chaires de Recherche du Canada), Ottawa, Ontario, Canada
-
Canadian Institutes of Health Research (CIHR)
-
Canadian Wireless Telecommunications Association (CWTA; Association canadienne des télécommunications sans fil (ACTS)), Canada
-
Cancer Council NSW, Australia
-
Cancer Council Victoria, Australia
-
Cancer Society of New Zealand
-
Department of Health, UK
-
Deutsches Mobilfunk Forschungsprogramm (DMF; German Mobile Phone Research Programme) at Federal Office for Radiation Protection (BfS)
-
Government of Canada
-
GSM Association, UK/Ireland
-
Guzzo Environment-Cancer Chair (University of Montréal) in partnership with Cancer Research Society (CRS) undertaken by the Environment-Cancer Fund, Canada
-
Hawkes Bay Medical Research Foundation (HBMR), New Zealand
-
Health and Safety Executive, UK
-
Health Research Council of New Zealand
-
International Union against Cancer (UICC; Union Internationale Contre le Cancer), Switzerland
-
Le Fonds de recherche du Québec – Santé (FRQS), Canada
-
MAIFOR Program (Mainzer Forschungsförderungsprogramm) of the University of Mainz, Germany
-
Ministerium für Klimaschutz, Umwelt, Landwirtschaft, Natur- und Verbraucherschutz Nordrhein-Westfalen (Ministry for Climate Protection, Environment, Agriculture, Conservation and Consumer Protection of the state of North Rhine-Westphalia), Germany
-
Ministerium für Umwelt, Klima und Energiewirtschaft, Baden-Württemberg (Ministry of the Environment, Climate Protection and the Energy Sector of the state of Baden-Württemberg), Germany
-
Mobile Manufacturers Forum (MMF), Belgium
-
Mobile Telecommunications and Health Research (MTHR), UK
-
National Institutes of Health (NIH), Maryland, USA
-
Natural Sciences and Engineering Research Council (NSERC) of Canada
-
O2
-
Orange
-
Quality of Life and Management of Living Resources program of European Union
-
Scottish Executive/Scottish Ministers, UK
-
SFR, France
-
T-Mobile
-
University of Sydney, Australia
-
Vodafone
-
Wellington Medical Research Foundation (WMRF), New Zealand
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