Studientyp:
Epidemiologische Studie
Amyotrophic lateral sclerosis, occupational exposure to extremely low frequency magnetic fields and electric shocks: a systematic review and meta-analysis
epidem.
[Amyotrophe Lateralsklerose, berufliche Exposition bei niederfrequenten Magnetfeldern und Stromschlägen: ein systematischer Review und Meta-Analyse]
Von:
Jalilian H, Najafi K, Khosravi Y, Röösli M
Veröffentlicht in: Rev Environ Health 2021; 36 (1): 129-142
Ziel der Studie (lt. Autor)
Weitere Details
Folgende 27 Studien wurden in die Meta-Analyse eingeschlossen: Deapen et al. (1986), Gunnarson et al. (1991), Gunnarson et al. (1992), Strickland et al. (1996), Davanipour et al. (1997), Savitz et al. (1998a), Savitz et al. (1998b), Noonan et al. (2002), Feychting et al. (2003), Hakansson et al. (2003), Park et al. (2005), Weißkopf et al. (2005), Röösli et al. (2007), Fang et al. (2009), Parlett et al. (2011), Malek et al. (2014), Sorahan et al. (2014), Fischer et al. (2015), Huss et al. (2015), Vergara et al. (2015), Koeman et al. (2017), Pedersen et al. (2017), Dickerson et al. (2019), Peters et al. (2019), Chen et al. (2019), Buckley et al. (1983) (nicht im EMF-Portal, weil Berufsbezeichnung ohne explixite Nennung von EMF enthalten ist) und Huisman el al. (2015, in Vorbereitung).
Endpunkt/Art der Risikoabschätzung
Exposition
Abschätzung
Population
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Gruppe:
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Beobachtungszeitraum:
1950 - 2016
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Studienort:
USA, Schweden, Dänemark, Schweiz, Großbritannien, Niederlande, Irland, Italien und Neuseeland
Statistische Analysemethode:
- Random-Effects-Modell, Meta-Regressions-Analyse, Heterogenitäts-Test, Funnel-Plot, Begg-Test, Egger-Test
Ergebnisse (lt. Autor)
Es wurde ein schwacher Zusammenhang zwischen beruflicher Exposition bei niederfrequenten Magnetfeldern und dem Risiko für amyotrophe Lateralsklerose gefunden (RR 1,20; KI 1,05-1,38). Es wurde kein Zusammenhang zwischen beruflicher Exposition bei Stromschlägen und dem Risiko für amyotrophe Lateralsklerose beobachtet (RR 0,97; KI 0,80-1,17). Für Elektroberufe wurde ein erhöhtes Risiko für amyotrophe Lateralsklerose (RR 1,22; KI 1,04-1,43) gefunden, jedoch nicht bei Schweißern, Lokomotivführern und Nähmaschinen-Bedienern.
Die Autoren schlussfolgerten, dass eine berufliche Exposition bei niederfrequenten Magnetfeldern, aber nicht bei Stromschlägen, ein Risikofaktor für amyotrophe Lateralsklerose sein könnte. Aufgrund der mäßigen bis hohen Heterogenität und einem möglichen Publikationsbias sollten die Ergebnisse jedoch mit Vorsicht interpretiert werden.
Studie gefördert durch
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Alborz University of Medical Sciences, Karaj, Iran
Themenverwandte Artikel
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Mezei G et al.
(2022):
Receipt of Electroconvulsive Therapy and Subsequent Development of Amyotrophic Lateral Sclerosis: A Cohort Study
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Chen GX et al.
(2021):
Associations of Occupational Exposures to Electric Shocks and Extremely Low-Frequency Magnetic Fields With Motor Neurone Disease
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Filippini T et al.
(2020):
Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study
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(2020):
Evaluation in humans of ELF-EMF exposure on chromogranin A, a marker of neuroendocrine tumors and stress
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Gunnarsson LG et al.
(2019):
Occupational Exposures and Neurodegenerative Diseases-A Systematic Literature Review and Meta-Analyses
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Associations of Electric Shock and Extremely Low-Frequency Magnetic Field Exposure With the Risk of Amyotrophic Lateral Sclerosis: The Euro-MOTOR Project
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Study of occupation and amyotrophic lateral sclerosis in a Danish cohort
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Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses
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