Enhancement of chemically induced reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells by 872 MHz radiofrequency radiation med./bio.

[Verstärkung der chemisch-induzierten reaktiven Sauerstoffspezies-Produktion und dem DNA-Schaden in humanen SH-SY5Y-Neuroblastom-Zellen durch 872 MHz Hochfrequenz-Befeldung]

Ziel der Studie (lt. Autor)

Hintergrund/weitere Details

Endpunkt

• Genotoxizität/Mutation: DNA-Schaden
• molekulare Biosynthese: Produktion reaktiver Sauerstoffspezies

Exposition/Befeldung (teilweise nur auf Englisch)

• • Hochfrequenz
• • CW (kontinuierliche Welle)
  • Mobilfunk
  • GSM
• • Ko-Exposition

Vollständige Ansicht Kompaktansicht

Methoden Endpunkt/Messparameter/Methodik

• Genotoxizität/Mutation: DNA-Schaden (Komet-Assay)
• molekulare Biosynthese: Produktion reaktiver Sauerstoffspezies (zu verschiedenen Zeitpunkten nach Exposition; Fluorimetrie)
• Zelllebensfähigkeit/Zellteilung/Zellproliferation: Zelllebensfähigkeit (Propidiumiodid-Färbung)

Hauptergebnis der Studie (lt. Autor)

Studie gefördert durch

• Finnish Cultural Foundation of Northern Savo
• Finnish Graduate School of Environmental Health (SYTYKE)
• Finnish mobile phone manufacturers and operators
• Ministry of Education, Finland
• Tekes (National Technology Agency), Finland

Themenverwandte Artikel

• Wang X et al. (2015): 8-oxoG DNA Glycosylase-1 Inhibition Sensitizes Neuro-2a Cells to Oxidative DNA Base Damage Induced by 900 MHz Radiofrequency Electromagnetic Radiation
• Luukkonen J et al. (2014): Induction of genomic instability, oxidative processes, and mitochondrial activity by 50Hz magnetic fields in human SH-SY5Y neuroblastoma cells
• Karaca E et al. (2012): The genotoxic effect of radiofrequency waves on mouse brain
• Luukkonen J et al. (2011): Pre-Exposure to 50 Hz Magnetic Fields Modifies Menadione-Induced Genotoxic Effects in Human SH-SY5Y Neuroblastoma Cells
• Poulletier de Gannes F et al. (2011): Effect of Exposure to the Edge Signal on Oxidative Stress in Brain Cell Models
• Xu S et al. (2010): Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons
• Luukkonen J et al. (2010): Combined effects of 872 MHz radiofrequency radiation and ferrous chloride on reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells
• Kumar S et al. (2010): Evaluation of genotoxic effects in male Wistar rats following microwave exposure
• Brescia F et al. (2009): Reactive oxygen species formation is not enhanced by exposure to UMTS 1950 MHz radiation and co-exposure to ferrous ions in Jurkat cells
• Gajski G et al. (2009): Radioprotective effects of honeybee venom (Apis mellifera) against 915-MHz microwave radiation-induced DNA damage in wistar rat lymphocytes: in vitro study
• Yao K et al. (2008): Electromagnetic noise inhibits radiofrequency radiation-induced DNA damage and reactive oxygen species increase in human lens epithelial cells
• Huang TQ et al. (2008): Characterization of biological effect of 1763 MHz radiofrequency exposure on auditory hair cells
• Zeni O et al. (2007): Formation of reactive oxygen species in L929 cells after exposure to 900 MHz RF radiation with and without co-exposure to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
• Simko M et al. (2006): Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells
• Lantow M et al. (2006): Free radical release and HSP70 expression in two human immune-relevant cell lines after exposure to 1800 MHz radiofrequency radiation
• Lantow M et al. (2006): ROS release and Hsp70 expression after exposure to 1,800 MHz radiofrequency electromagnetic fields in primary human monocytes and lymphocytes