Relationship between amyloid beta protein and melatonin metabolite in a study of electric utility workers med./bio.

[Beziehung zwischen dem Amyloid-Beta-Protein und dem Melatonin-Metabolit in einer Untersuchung von Elektrizitätswerks-Mitarbeitern]

Ziel der Studie (lt. Autor)

Hintergrund/weitere Details

Endpunkt

• molekulare Biosynthese: Konzentration des Amyloid-Beta-Proteins
• endokrine Veränderungen: Konzentration des Melatonin-Metaboliten 6-Hydroxymelatoninsulfat

Exposition/Befeldung (teilweise nur auf Englisch)

• • 50/60 Hz
  • magnetisches Feld
• • Umspannwerk
• • berufliche Exposition

Vollständige Ansicht Kompaktansicht

Methoden Endpunkt/Messparameter/Methodik

• molekulare Biosynthese: Konzentration des Amyloid-Beta-Proteins im Urin (2 Längen des Proteins (Aminosäuren 1-40 und 1-42); ELISA)
• endokrine Veränderungen: Konzentration von 6-Hydroxymelatoninsulfat im Plasma (Radioimmunoassay)
• Fragebogen zu Arbeits-Aktivitäten, zur derzeitigen medizinischen Verfassung, Familiengeschichte in Hinblick auf neurodegenerative Bedingungen, Aluminium-Exposition, usw.

Hauptergebnis der Studie (lt. Autor)

Studie gefördert durch

• National Institute of Environmental Health Sciences (NIEHS), North Carolina, USA
• National Institutes of Health (NIH), Maryland, USA
• Platte River Power Authority (PRPA), USA

Themenverwandte Artikel

• Tiwari R et al. (2013): The Potential Bioeffects of Extremely Low Frequency Electromagnetic Fields on Melatonin Levels & Related Oxidative Stress in Electric Utility Workers Exposed to 132 kV Substation
• Zhang C et al. (2013): Extremely low-frequency magnetic exposure appears to have no effect on pathogenesis of Alzheimer's disease in aluminum-overloaded rat
• Clark ML et al. (2007): Biomonitoring of estrogen and melatonin metabolites among women residing near radio and television broadcasting transmitters
• Del Giudice E et al. (2007): Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid peptide in cultured human neuroglioma
• Gobba F et al. (2006): No association between occupational exposure to ELF magnetic field and urinary 6-sulfatoximelatonin in workers
• Davis S et al. (2006): Effects of 60-Hz magnetic field exposure on nocturnal 6-sulfatoxymelatonin, estrogens, luteinizing hormone, and follicle-stimulating hormone in healthy reproductive-age women: results of a crossover trial
• Ichinose TY et al. (2004): Immune markers and ornithine decarboxylase activity among electric utility workers
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• Karasek M et al. (2002): Melatonin and magnetic fields
• Lerchl A (2002): Die Melatonin-Hypothese. Eine Einführung
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