この研究は、携帯電話から放射される無線周波電磁界(RF:1800MHz)のラット脳への影響を調べた。雄ラット(n=40)を無作為にばく露群と対照群(それぞれn=20)に無作為に分け、ばく露群は、携帯電話(SARの表示値0.6W/kg)からのRFばく露を1日2時間、3ヵ月間継続した。実験期間終了後、脳を摘出し、海馬と小脳について生化学的、組織学的、免疫組織化学的および電子顕微鏡的な検査を行った。その結果、ばく露群の両領域において、マロンジアルデヒドの有意な上昇、抗酸化パラメータ(グルタチオン、スーパーオキシドジスムターゼ、グルタチオン・ペルオキシダーゼ)の有意な低下が観察された;変性的変化が、海馬錐体細胞、暗細胞、小脳プルキンエ細胞で見られ、血管の鬱血を伴った;DNA断片化、アポトーシス関連COX-2 遺伝子の発現過剰が見られた、と報告している。
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The effects of exposure of rats to a 1800 MHz electromagnetic field on oxidative stress, DNA damage and histology in the brain should be investigated.
40 male rats were divided into two groups (n=20 each): 1) exposure group and 2) control group.
周波数 | 1,800 MHz |
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タイプ |
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ばく露時間 | continuous for 120 min/day for three months |
ばく露の発生源/構造 |
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Distance between measurement device and exposed object | 5 cm |
ばく露装置の詳細 | each group was placed in four cages (five rats per cage); one mobile phone was placed in the bottom of each cage at the center under a wire mesh to give maximum exposure near the brain. |
Additional information | the control group was placed in four cages (five rats per cage) in a separate room away from any mobile phones |
Oxidative stress was significantly increased in hippocampus and cerebellum samples from exposed animals compared to the control group, while antioxidant parameters (content of reduced glutathione, enzyme activities of glutathione peroxidase and superoxide dismutase) were significantly decreased.
The amount of cyclooxygenase-2 was significantly increased in hippocampus and cerebellum samples from exposed animals compared to the control group, indicating increased neural damage.
DNA fragmentation was also significantly increased in hippocampus and cerebellum samples of the exposure group compared to the control group.
Histological and ultrastructural analysis showed degenerative changes in hippocampal pyramidal cells and dark cells and cerebellar Purkinje cells with vascular congestion in the exposure group and normal appearance in the control group.
The authors conclude that exposure of rats to a 1800 MHz electromagnetic field might lead to oxidative stress, DNA damage and histological changes in the brain.
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