研究のタイプ: 医学／生物学の研究 (experimental study)

[900 MHzGSM携帯電話はラットの脳に影響するか] med./bio.

Does 900 MHz GSM Mobile Phone Exposure Affect Rat Brain?

著者: Dasdag S, Akdag Z, Aksen F
掲載誌: Electromagn Biol Med 2004; 23 (3): 201-214
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この研究は、携帯電話ばく露がラット脳におけるリン脂質の脂肪酸組成、マロンジアルデヒド濃度、p53免疫反応性、および組織学的構造に及ぼす影響を調べた。16匹のSprague-Dawleyラットを、8匹ずつの擬似ばく露群とばく露群（携帯電話の通話モードへのばく露）に分けた。ラットをプレキシグラス製のケージに入れ、携帯電話をケージの下0.5 cmに置いた。ばく露群では、携帯電話の電源を1日20分間オンにすることを、週7日で、1か月間継続した。擬似ばく露群ではケージの下の携帯電話の電源はオフであった。全身平均SAR（rms）は0.52 W / kgで、1 gの平均ピークSAR（rms）3.13 W/ kgであった。Mann-Whitney U検定を用いて両群のデータを比較した。その結果、脳の組織学的変化、リン脂質の脂肪酸組成の変化は観察されなかった；脳組織の免疫組織化学染色により、p53の免疫反応性は携帯電話ばく露の影響を受けないことが示された；ばく露群の脳のマロンジアルデヒド濃度は、擬似ばく露群に比べ有意に高かった（p < 0.05）、と報告している。

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研究目的（著者による）

To study the effects of cell phone exposure on the fatty acid composition in phospholipids, malondialdehyde concentration, p53 immune reactivity and histological structure of the rat brain.

詳細情報

It is suggested that p53 immune reactivity may be related to the change of fatty acid composition in phospholipids. The loss of p53 appears to sensitize cells to fatty acid synthase inhibitors, and raises the possibility that these agents may be clinically useful against malignancies.
Malondialdehyde is a marker for lipid peroxidation, free radical damage, and oxidative stress. Lipid peroxidation may induce p53 immune reactivity.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 890–915 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure, 20 min/day for 1 month

ばく露1

主たる特性
周波数 890–915 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 20 min/day for 1 month
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Additional information

DTX (discontinuous transmission mode) was activated. The phones were in speech condition sending a tape of human speech to the base station.
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
Distance between exposed object and exposure source 0.5 cm
チャンバの詳細 The rats were confined in Plexiglas cages (20 cm x 10.5 cm x 10 cm) with ventilation holes, and the cellular phones were placed 0.5 cm under the cages.
ばく露装置の詳細 Exposure began after the rats had selected a fixed location and settled into a prone position. The feed point of the antenna was placed under the cage against the brain.
Additional information For sham exposure, the setup was identical, except that the phone was switched off.
パラメータ
測定量 値 種別 Method Mass 備考
電力 2 W peak - - -
電力 250 mW mean - - -
電界強度 13.59 V/m mean 測定値 - -
電力密度 0.047 mW/cm² mean 測定値 - -
SAR 3.13 W/kg effective value 計算値 1 g -
SAR 0.52 W/kg effective value 測定値および計算値 whole body 0.29-0.87 W/kg
Additional parameter details

Measured background levels of EMF were 0.22 V/m and 0.0001 mW/cm².

測定および計算の詳細

The FDTD method was used to calculate the SAR. The simulation was performed using Finite Integration Technique (FIT) which in the time domain case is similar to FDTD. The FCC recommended parameters for average muscle dielectric constant and conductivity at 900 MHz were used to simulate the rat model which was an ellipsoid with 100 mm and 28 mm semi axis. The phone model was a metallic box of 90 mm x 40 mm x 15 mm mounted with a monopole antenna of 80 mm. Distance between the rat model and the phone model was 5 mm. Taking into account the very simple shape of the model used in this simulation, the SAR values are approximate. In addition, due to the adaptive power control of the base station, the radiated power was variable during the study. Therefore, minimum and maximum SAR levels were measured. Average electric field and power density were measured by a radiation meter. An equipment called ''cell sensor'' was used for checking the availability of the signal.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Histological alteration and changes in brain phospholipid fatty acids composition were not found in the brains. p53 immune reactivity was not affected by cell phone exposure. Malondialdehyde concentration in exposed brains was significantly higher than in sham-exposed brains. The alteration in malondialdehyde does not appear sufficient to induce histological changes in brain tissue.

研究の種別:

研究助成

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