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研究目的（著者による）
The effects of a chronic exposure of rats to a 50 Hz magnetic field on liver damage, immunologic parameters and oxidative stress in serum, liver and spleen should be investigated.
詳細情報
32 rats were divided into 4 groups (probably n=8 each; not specified): exposure to a magnetic field with 1) 5 mT, 2) 10 mT or 3) 20 mT and 4) sham exposure.
a pair of Helmholtz coils with a mean radius of 15 ± 0.3 cm, respectively, and a mean horizontal distance of 15 ± 0.5 cm between the coils was positioned vertically to the horizontal plane; temperature was maintained at 22°C
免疫系への影響: immunoglobulin content (IgG, IgA, and IgM; automatic biochemical analyzer) in serum
oxidative stress (lipid peroxidation (reaction of malondialdehyde with thiobarbituric acid), enzyme activities of glutathione peroxidase (reaction with Ellman's reagent) and superoxide dismutase (xanthine oxidase method) (spectrophotometry)) in serum, liver and spleen; liver damage (enzyme activities of alanine aminotransferase and aspartate aminotransferase; automatic biochemical analyzer) in serum
The content of all immunoglobulins in the serum decreased gradually with increasing intensity of the magnetic field exposure, with all exposure groups (groups 1-3) showing significantly reduced values compared to the sham exposure group. Likewise, the enzyme activities of alanine aminotransferase and aspartate aminotransferase in the serum increased gradually with increasing intensity of the magnetic field exposure, with all exposure groups showing significantly higher values than the sham exposure group. Oxidative stress was increased in serum, liver and spleen with increasing intensity of the magnetic field, with groups 2 (10 mT) and 3 (20 mT) showing a significant increased lipid peroxidation and significant decreased superoxide dismutase and glutathione peroxidase enzyme activities compared to the sham exposure group. The authors conclude that chronic exposure of rats to a 50 Hz magnetic field might have detrimental effects on the liver and immunologic parameters and could induce oxidative stress in serum, liver and spleen.
