Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields med./bio.

[Klastogenität und Aneuploidie bei neugeborenen und adulten Mäusen, die bei 50 Hz-Magnetfeldern exponiert waren]

Ziel der Studie (lt. Autor)

Hintergrund/weitere Details

Endpunkt

• Genotoxizität/Mutation: klastogene und aneugene Wirkungen

Exposition/Befeldung (teilweise nur auf Englisch)

• • 50/60 Hz
  • magnetisches Feld
  • Niederfrequenz

Vollständige Ansicht Kompaktansicht

Methoden Endpunkt/Messparameter/Methodik

• Genotoxizität/Mutation: klastogene und aneugene Wirkungen (Mikronukleus-Assay mit CREST-Antikörper (zum Nachweis, ob Zentromer-Proteine vorhanden sind oder fehlen); Immunofluoreszenz)

Hauptergebnis der Studie (lt. Autor)

Studie gefördert durch

• Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro (ISPESL; National Institute for Occupational Safety and Prevention), Italy

Themenverwandte Artikel

• Udroiu I et al. (2015): Genotoxicity induced by foetal and infant exposure to magnetic fields and modulation of ionising radiation effects
• Miyakoshi Y et al. (2012): Tempol suppresses micronuclei formation in astrocytes of newborn rats exposed to 50-Hz, 10-mT electromagnetic fields under bleomycin administration
• Mariucci G et al. (2010): Brain DNA damage and 70-kDa heat shock protein expression in CD1 mice exposed to extremely low frequency magnetic fields
• Okudan N et al. (2010): Effects of long-term 50 Hz magnetic field exposure on the micro nucleated polychromatic erythrocyte and blood lymphocyte frequency and argyrophilic nucleolar organizer regions in lymphocytes of mice
• McNamee JP et al. (2005): Evaluating DNA damage in rodent brain after acute 60 Hz magnetic-field exposure
• Winker R et al. (2005): Chromosomal damage in human diploid fibroblasts by intermittent exposure to extremely low-frequency electromagnetic fields
• Vijayalaxmi et al. (2005): Controversial cytogenetic observations in mammalian somatic cells exposed to extremely low frequency electromagnetic radiation: a review and future research recommendations
• Yokus B et al. (2005): Oxidative DNA damage in rats exposed to extremely low frequency electro magnetic fields
• Wolf FI et al. (2005): 50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism
• Stronati L et al. (2004): Absence of genotoxicity in human blood cells exposed to 50 Hz magnetic fields as assessed by comet assay, chromosome aberration, micronucleus, and sister chromatid exchange analyses
• Testa A et al. (2004): Evaluation of genotoxic effect of low level 50 Hz magnetic fields on human blood cells using different cytogenetic assays
• Ding GR et al. (2003): Induction of kinetochore-positive and kinetochore-negative micronuclei in CHO cells by ELF magnetic fields and/or X-rays
• Ivancsits S et al. (2003): Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields
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• Verheyen GR et al. (2003): Effect of coexposure to 50 Hz magnetic fields and an aneugen on human lymphocytes, determined by the cytokinesis block micronucleus assay
• Ivancsits S et al. (2002): Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts
• McNamee JP et al. (2002): DNA damage and apoptosis in the immature mouse cerebellum after acute exposure to a 1 mT, 60 Hz magnetic field
• Abramsson-Zetterberg L et al. (2001): Extended exposure of adult and fetal mice to 50 Hz magnetic field does not increase the incidence of micronuclei in erythrocytes
• Yaguchi H et al. (2000): Increased chromatid-type chromosomal aberrations in mouse m5S cells exposed to power-line frequency magnetic fields
• Svedenstal BM et al. (1999): DNA damage, cell kinetics and ODC activities studied in CBA mice exposed to electromagnetic fields generated by transmission lines
• Svedenstal BM et al. (1999): DNA damage induced in brain cells of CBA mice exposed to magnetic fields
• Lai H et al. (1997): Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells
• Mailhes JB et al. (1997): Electromagnetic fields enhance chemically-induced hyperploidy in mammalian oocytes
• Lai H et al. (1997): Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells