本研究では、6つの独立した機関の共同研究として、無線周波（RF）電磁界（GSM、1800MHz）による遺伝毒性作用の可能性を、ヒトリンパ球で調査した。二つの年齢グループの20人の健康な非喫煙者のボランティア（16-20歳の10人、50-65歳の10人）の末梢血を採取し、3つのSAR（0.2、2、10W/kg）のRF電磁界に28時間の間欠的ばく露、または擬似ばく露した。染色体異常試験（5種類の構造異常）、小核試験、姉妹染色分体交換試験、アルカリ・コメットアッセイ（テイルモーメントおよび％DNA）をエンドポイントとした遺伝毒性試験を実施した。その結果、9つのエンドポイントはいずれも有意ではなく、再現性のあるばく露の影響は認められなかった、と報告している。なお共同研究の分担は、標本採取・ばく露実験・遺伝毒性試験を研究機関A、ばく露条件設定・SAR計算を研究機関H、遺伝毒性試験の検証（ばく露条件は非通知で）を独立的に研究機関C、D、E、統計的分析を研究機関Bが行った。
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To investigate possible genotoxic effects of an exposure to 1.8 GHz-electromagnetic fields on isolated peripheral human lymphocytes.
20 blood samples of two age groups (10 volunteers 16-20 years old, 10 volunteers 50-65 years old) were stimulated with PHA, exposed to three different specific absorption rates and investigated.
Positive controls were performed for every blood sample and each test. The study was a collaboration of six independent institutes. Genotoxic tests were conducted by one institute and evaluated by three different institutes. Three institutes were responsible for blood collection and exposure, exposure design, and statistical analysis.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
1,800 MHz
Modulation type:
pulsed
ばく露時間:
intermittent (5 min on, 10 min off) for 28 hours
|
|
|
ばく露2:
1,800 MHz
Modulation type:
pulsed
ばく露時間:
intermittent (5 min on, 10 min off) for 28 hours
|
|
|
ばく露3:
1,800 MHz
Modulation type:
pulsed
ばく露時間:
intermittent (5 min on, 10 min off) for 28 hours
|
|
| 周波数 | 1,800 MHz |
|---|---|
| タイプ |
|
| 波形 |
|
| ばく露時間 | intermittent (5 min on, 10 min off) for 28 hours |
| Modulation type | pulsed |
|---|---|
| Repetition frequency | 217 Hz |
| ばく露の発生源／構造 | |
|---|---|
| ばく露装置の詳細 | eight waveguides arranged in four separately controlled exposure units (containing 72 culture dishes of 35 mm in diameter); in each waveguide, one dish holder with 9 cell culture dishes; each exposure unit consisted of a power splitter connecting two single-mode cavities for 1.8 GHz that are based on R18 waveguides; the system was capable of driving four different power levels in parallel that are randomly assigned to the four exposure units; two waveguides (18 dishes) per SAR; eight waveguides mounted on an aluminium rack; system placed in an incubator with constant environmental conditions |
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 0.2 W/kg | - | - | - | - |
| 周波数 | 1,800 MHz |
|---|---|
| タイプ |
|
| 波形 |
|
| ばく露時間 | intermittent (5 min on, 10 min off) for 28 hours |
| Modulation type | pulsed |
|---|---|
| Repetition frequency | 217 Hz |
| ばく露の発生源／構造 |
|
|---|
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 2 W/kg | - | - | - | - |
| 周波数 | 1,800 MHz |
|---|---|
| タイプ |
|
| 波形 |
|
| ばく露時間 | intermittent (5 min on, 10 min off) for 28 hours |
| Modulation type | pulsed |
|---|---|
| Repetition frequency | 217 Hz |
| ばく露の発生源／構造 |
|
|---|
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 10 W/kg | - | - | - | - |
Between the laboratories, strong differences occurred, but only results with a significant result found by at least two institutes were ascertained to indicate an exposure effect. Therefore, none of the examined endpoints showed a significant and reproducible exposure effect.
In general, the results showed no evidence of a genotoxic effect of exposure to 1.8 GHz-electromagnetic fields in isolated peripheral human lymphocytes.
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