研究のタイプ: 医学／生物学の研究 (experimental study)

[高周波電磁界への急性ばく露後のラットの中枢神経系に対する酸化的ストレス効果] med./bio.

Oxidative stress effects on the central nervous system of rats after acute exposure to ultra high frequency electromagnetic fields

著者: Ferreira AR, Bonatto F, de Bittencourt Pasquali MA, Polydoro M, Dal-Pizzol F, Fernandez C, de Salles AA, Moreira JC
掲載誌: Bioelectromagnetics 2006; 27 (6): 487-493
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この研究は、ラットの前頭皮質および海馬における非酵素的抗酸化防御ならびに脂質とタンパク質の酸化的損傷に対する超高周波電磁界（UHF-EMF）の急性ばく露の影響を調べた。脂質およびタンパク質の酸化的損傷はそれぞれ、マロンジアルデヒド（MDA）アッセイおよびカルボニルアッセイを用いて評価した。その結果、前頭皮質または海馬において、脂質とタンパク質の損傷、および非酵素的抗酸化防御の変化は観察されなかった；これらの知見は、試験したどの年齢のラットにおいても、UHF-EMFへの急性ばく露は検出可能な酸化ストレスを生じさないことを示唆している、と報告している。

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研究目的（著者による）

To study the effect of acute ultrahigh frequency electromagnetic field exposure on non-enzymatic antioxidant defense and lipid and protein oxidative damage in the rat frontal cortex and hippocampus.

詳細情報

A total of 31 rats were divided by age into three groups (30, 80, and 210 days) and exposed.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 834 MHz
ばく露時間: repeated daily exposure, 7.5 h per day, for 6 days
  • 電力: 600 mW peak
  • 電界強度: 35.7 V/m effective value (23-35.7 V/m)
  • 磁界強度: 90 mA/m (65-90 mA/m)
  • 電力密度: 0.35 mW/cm² mean (0.15-0.35 mW/cm²)
  • SAR: 0.98 W/kg (0.41-0.98 W/kg for 30 days old rats)
  • SAR: 0.86 W/kg (0.36-0.86 W/kg for 70 days old rats)

ばく露1

主たる特性
周波数 834 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 7.5 h per day, for 6 days
Additional information vertical polarisation
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
  • in test mode
Distance between exposed object and exposure source 20 cm
チャンバの詳細 The animal exposure cage (total diameter 93 cm, height 33 cm in the center and 24 cm at the periphery) was divided into four compartments (1276.27 cm² each) placed around an inner compartment (1256.64 cm², r = 20 cm) and was made of wood (floor and inner walls) and transparent plastic (lining the floor and outer wall) covered by a galvanised steel net (1.5 x 1.5 cm mesh).
ばく露装置の詳細 The mobile phone was positioned in the center of the middle compartment, and the extremity of the antenna was in contact with the floor. The animals were placed in one of the compartments, and their distance from the antenna varied from 20 to 45 cm.
Sham exposure A sham exposure was conducted.
Additional information The sham exposure cage was placed 40.5 cm away from the real exposure cage.
パラメータ
測定量 値 種別 Method Mass 備考
電力 600 mW peak - - -
電界強度 35.7 V/m effective value 測定値 - 23-35.7 V/m
磁界強度 90 mA/m - 測定値 - 65-90 mA/m
電力密度 0.35 mW/cm² mean 測定値 - 0.15-0.35 mW/cm²
SAR 0.98 W/kg - 計算値 - 0.41-0.98 W/kg for 30 days old rats
SAR 0.86 W/kg - 計算値 - 0.36-0.86 W/kg for 70 days old rats
測定および計算の詳細

The field intensity was measured with a radiofrequency spectrum analyzer and electromagnetic field meters. The parameters for the rats were measured according to [Peyman et al., 2001].

Reference articles

  • Peyman A et al. (2001): [マイクロ波周波数でのラット組織の誘電特性の年齢の関数としての変化]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

No changes in lipid and protein damage, and also in non-enzymatic antioxidant defense were found in frontal cortex or hippocampus. These data indicate that acute ultrahigh frequency electromagnetic field exposure is not able to produce detectable oxidative stress in rats from any age tested.

研究の種別:

研究助成

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