この研究は、マウスの腫瘍発生および繁殖力に対する超低周波電磁界の長期ばく露の影響を調べた。C57BL/6NCrj妊娠マウス(n=10)に50Hzの磁界(500mG)のばく露を1日12時間、1週間与え、それらから生まれたB6C3F1マウス(雄24匹、雌42匹)をばく露群として、さらに15.5ヶ月間、同じばく露を与えた。対照群として、無ばく露の妊娠マウス(n=10)から生まれた雄30匹、雌32匹を無ばく露で同じ期間観察した。その結果、ばく露群の平均体重は雄、雌とも対照群に比べ有意に低かった;肝臓および肺の腫瘍発生率への影響は無かった;雌において、慢性骨髄性白血病の発生率が対照群に比べばく露群で有意に高かった;精細管の大きさが対照群に比べばく露群で有意に小さかった、と報告している。
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The effects of a chronic exposure of mice to a 50 Hz magnetic field on the incidence of cancer, organ weights and male fertility should be investigated.
The offspring of 10 pregnant mice, which were exposed to the magnetic field during their last week of pregnancy until birth, were used as the exposure group (n=66). The offspring was further exposed after birth for 15.5 months. The offspring of 10 pregnant mice without exposure used for control group (n=62).
ばく露 | パラメータ |
---|---|
ばく露1:
50 Hz
ばく露時間:
continuous for 12 hours per day for 1 week before birth (in utero) and 15.5 months after birth
|
|
周波数 | 50 Hz |
---|---|
タイプ |
|
ばく露時間 | continuous for 12 hours per day for 1 week before birth (in utero) and 15.5 months after birth |
ばく露の発生源/構造 |
|
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チャンバの詳細 | wire cages |
ばく露装置の詳細 | environmental conditions were 23 ± 2°C and 50 ± 10% humidity |
測定量 | 値 | 種別 | Method | Mass | 備考 |
---|---|---|---|---|---|
磁束密度 | 50 µT | - | - | - | - |
The body weight and weight of the liver of exposed animals were significantly decreased compared to the control group.
In exposed animals, the incidence of chronic myeloid leukemia was significantly greater compared to the control group.
The seminiferous tubules diameter was significantly reduced in exposed animals in comparison to the control group.
The authors conclude that a chronic exposure of mice to a 50 Hz magnetic field might increase the incidence of chronic myeloid leukemia and could have a detrimental effect on the male fertility.
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