この研究は、ヒト絨毛細胞株HTR-8/Svneoでのタンパク質発現(HSP70,HSC70)、遺伝子発現(HSP70A,B,CおよびHSC70)および一次的DNA損傷反応に対する非熱的レベルの217Hzパルス変調1817MHz正弦波(EMFs:ばく露時間:1時間、SAR:2 W/kg)の影響を調べた。その結果、EMFsばく露群では、HSP70またはHSC70のタンパク質および遺伝子発現に有意な変化がなかった;DNA鎖切断への影響は観察されなかった、と報告している。
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To determine whether radiofrequency electromagnetic fields could induce cellular effects in trophoblast cells.
The effects observed after radiofrequency exposure were compared to those caused by heat (43°C, 1 h) or hydrogen peroxide, which were used as positive controls.
Trophoblast cells have not been used previously in similar experiments. However, their high proliferation and invasion capability, their fine modulation by physiological factors, and their high sensitivity to external stimuli, make these cells an attractive model for investigating possible detrimental effects of radiofrequency electromagnetic fields on cell physiology.
ばく露 | パラメータ |
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ばく露1:
1,817 MHz
Modulation type:
pulsed
ばく露時間:
continuous for 1 h
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周波数 | 1,817 MHz |
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タイプ |
|
波形 |
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特性 |
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ばく露時間 | continuous for 1 h |
ばく露の発生源/構造 | |
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チャンバの詳細 | The exposure system [Schonborn et al., 2000] located inside an incubator consisted of two 128.5 x 65 x 424 mm³ brass single-mode waveguide resonators (equipped with DC ventilators) that were assigned to exposure or sham condition by the computer-controlled signal unit ensuring blind conditions for the experiment. |
ばく露装置の詳細 | Each resonator was equipped with a plastic holder holding six 35-mm Petri dishes arranged in two stacks in the H-field maxima of the standing wave (E-polarization). |
Sham exposure | A sham exposure was conducted. |
Additional information | More than 90% of the power coupled into the waveguides was reflected and directed into a 50-Ω terminator via the circulator (included in the amplifier). |
測定量 | 値 | 種別 | Method | Mass | 備考 |
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SAR | 2 W/kg | average over time | 測定値および計算値 | - | - |
No evidence was found that a 1 h exposure to GSM 217 Hz induced a HSP70-mediated stress response or primary DNA damage in HTR-8/SVneo cell line.
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