この研究は、既知の化学変異原(4-ニトロキノリン-N-オキシド:4NQO)と1800 MHz無線周波GSM信号の組み合わせばく露が、ヒトTHP1細胞に及ぼす影響を調べた。コメットおよびγ-H2AXアッセイを使用して、DNA損傷を評価した。その結果、ばく露中(2時間)、細胞培養物の加熱は認められなかった;培地のSAR値が2 - 16 W / kgの範囲の電磁界ばく露は、4NQOによって誘発されるDNA損傷を増加させなかった;一方、少なくとも4°Cの温度上昇があると、DNA鎖切断の数は増加した;以上の知見から、加熱を引き起こさない程度のばく露レベルの無線周波電磁界に共遺伝毒性効果は見られないことが示唆された、と報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
To study the effect of a 1800 MHz radiofrequency GSM signal combined with a known chemical mutagen (4-nitroquinoline-N-oxide: 4NQO) on human cells.
No heating of the cell cultures was detected during exposure. Additional experiments were performed at 37, 39, 41 or 43°C (2 h, with 4NQO).
cells were treated in four groups: i) sham exposure ii) EMF exposure iii) 1.8 µM 4NQO (4-nitroquinoline-N-oxide) + sham exposure iv) 1.8 µM 4NQO + EMF exposure
周波数 | 1,800 MHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | continuous for 2 h |
Modulation type | pulsed |
---|---|
Duty cycle | 12.5 % |
Repetition frequency | 217 Hz |
ばく露の発生源/構造 | |
---|---|
Distance between exposed object and exposure source | 1 m |
チャンバの詳細 | three identical exposure chambers used - two for simultaneous exposures and one for sham exposure |
ばく露装置の詳細 | cells placed in Petri dishes inside thermoregulated Plexiglas incubators which were slowly rotated and positioned each inside an anechoic chamber; temperature inside the incubator 37°C; layer of small glass balls with a diameter of 1.5 mm placed inside the Petri dishes for efficient heat conduction; rectangular horn antenna positioned above the incubator; |
Sham exposure | A sham exposure was conducted. |
The exposure of cells to electromagnetic fields with SARs of 2 to 16 W/kg did not increase the DNA damage induced by 4NQO, whereas the number of DNA strand breaks increased with a temperature rise of at least 4 °C. In conclusion, no co-genotoxic effect of radiofrequency electromagnetic field exposure was found at levels of exposure that did not induce heating.
このウェブサイトはクッキー(Cookies)を使って、最善のブラウジングエクスペリエンスを提供しています。あなたがこのウェブサイトを継続して使用することで、私たちがクッキーを使用することを許可することになります。