Effects of exposure to 1.8 GHz radiofrequency field on the expression of Hsps and phosphorylation of MAPKs in human lens epithelial cells med./bio.

[Wirkungen der Exposition bei einem 1,8 GHz-Hochfrequenz-Feld auf die Expression von Hsps und die Phosphorylierung von MAPKs in menschlichen Augenlinsen-Epithelzellen]

Ziel der Studie (lt. Autor)

Endpunkt

• molekulare Biosynthese: Proteinexpression von Hitzeschock-Proteinen
• Aktivierung (Phosphorylierung) der Mitogen-aktivierten Proteinkinase

Exposition/Befeldung (teilweise nur auf Englisch)

• • 1,8 GHz
• • Mobilfunk
  • digitales Mobiltelefon
  • GSM

Vollständige Ansicht Kompaktansicht

Methoden Endpunkt/Messparameter/Methodik

• molekulare Biosynthese: Proteinexpression von Hitzeschock-Proteinen (Hsp90, Hsp70, Hsp27; Western Blot)
• Aktivierung (Phosphorylierung) der Mitogen-aktivierten Proteinkinase (ERK-1/2, JNK-1/2, p38 MAPK; Western Blot)

Hauptergebnis der Studie (lt. Autor)

Studie gefördert durch

• National Natural Science Foundation (NSFC), China
• Zhejiang Provincial Natural Science Foundation, China

Themenverwandte Artikel

• Valbonesi P et al. (2014): Effects of the exposure to intermittent 1.8 GHz radio frequency electromagnetic fields on HSP70 expression and MAPK signaling pathways in PC12 cells
• Terro F et al. (2012): GSM-900MHz at low dose temperature-dependently downregulates alpha-synuclein in cultured cerebral cells independently of chaperone-mediated-autophagy
• Kim HN et al. (2012): Analysis of the cellular stress response in MCF10A cells exposed to combined radio frequency radiation
• Ding GR et al. (2009): Comparison of Hsps expression after radio-frequency field exposure in three human glioma cell lines
• Dawe AS et al. (2008): Continuous wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans
• Lee KS et al. (2008): Mobile phone electromagnetic radiation activates MAPK signaling and regulates viability in Drosophila
• Franzellitti S et al. (2008): HSP70 expression in human trophoblast cells exposed to different 1.8 Ghz mobile phone signals
• Friedman J et al. (2007): Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies
• Hirose H et al. (2007): Mobile phone base station-emitted radiation does not induce phosphorylation of Hsp27
• Sanchez S et al. (2007): In Vitro Study of the Stress Response of Human Skin Cells to GSM-1800 Mobile Phone Signals Compared to UVB Radiation and Heat Shock
• Vanderwaal RP et al. (2006): HSP27 phosphorylation increases after 45°C or 41°C heat shocks but not after non-thermal TDMA or GSM exposures
• Sanchez S et al. (2006): Human skin cell stress response to GSM-900 mobile phone signals. In vitro study on isolated primary cells and reconstructed epidermis
• Miyakoshi J et al. (2005): Effects of exposure to a 1950 MHz radio frequency field on expression of Hsp70 and Hsp27 in human glioma cells
• Leszczynski D et al. (2002): Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer- and blood-brain barrier-related effects
• Kwee S et al. (2001): Changes in cellular proteins due to environmental non-ionizing radiation. I. Heat-shock proteins