この研究は、SDラット（ばく露群および擬似ばく露群：各n=64）に50Hz、100μTの磁界ばく露（または擬似ばく露）を1日20時間、24週間を与え、心血管系への影響を調べた。ばく露（または擬似ばく露）中、4週間に1回、血圧を測定した。24週間後に心エコー検査、心臓カテーテル検査、心電図検査を実施した後、心臓重量、体重を記録、組織検査などを行った。その結果、血圧、心拍数とリズムにばく露群と擬似ばく露群との差はなかった；心エコーおよび心臓カテーテル検査による心臓の形態または血流動態にも差がなかった；心臓組織の組織病理学的検査および心肥大関連遺伝子発現にも差がみられなかった､と報告している。
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The effects of chronic exposure of rats to a 50 Hz magnetic field on the cardiovascular system should be investigated.
Male rats were divided into 2 groups (n=64 each): 1) exposure to the magnetic field and 2) sham exposure.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
50 Hz
ばく露時間:
intermittent 20 hours/day for 24 weeks
|
|
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | intermittent 20 hours/day for 24 weeks |
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | polycarbonate ventilated cages (45 cm x 20 cm x 35 cm, L x W x H) with room temperature of 22-25°C and relative humidity of 45-55% |
| ばく露装置の詳細 | exposure system consisted of an exposure device and a plastic rack, both made of acrylonitrile butadiene styrene plastic; the exposure device had five layers (200 cm x 100 cm x 200 cm, L x W x H) with a layer-to-layer distance of 35 cm; inside the exposure device, a plastic rack (140 cm x 70 cm x 200 cm, L x W x H) with four floors was placed; 24 plastic cages with 2-3 rats each were placed inside the system; bronze wires generated the uniform magnetic field; the wiring ratio of the five coils was 2:1:1:1:2 and the 3% uniformity area of each floor was 150 cm x 50 cm (L x W) and over the whole rack, uniformity was 5.2%; sound and temperature from the exposure system were close to those in the environment; exposure room was lacking other electric devices, e.g., computers and daylight lamps were kept far away from the system |
| Sham exposure | A sham exposure was conducted. |
| Additional information | currents in coils were in opposite directions in sham exposure system; exposure and sham exposure systems were located in separated and non-adjacent rooms with similar conditions |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 100 µT | - | 測定値 | - | - |
No significant differences were found between the exposure and sham-exposure group.
The authors conclude that there were no effects of chronic exposure of rats to a 50 Hz magnetic field on the cardiovascular system.
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