この研究は、ラットを2.45GHzWi-Fi信号（RF）にばく露し、生じた影響およびその影響に対するオリーブ葉抽出物（OLE）の防護的作用の有無を調べた。Wister系雄ラット24匹を6匹ずつの4群に分けた；対照群（RF擬似ばく露､生食液の腹腔内注射）、OLE群（RF擬似ばく露、OLEの腹腔内注射）、RF群（RFばく露､生食液の腹腔内注射）RF+OLE群（RFばく露、OLEの腹腔内注射）。RFばく露は､ラットを入れたケージをWiFi装置（2.45GHz）のアクセスポイントの下に置いて行ったと記されている（擬似ばく露時にはWiFi装置の電源オフ）。ばく露時間は1日1時間で、21日連続した。その結果、RF群では、糖尿病状態が誘導された；肝臓と腎臓のグルタチオンペルオキシダーゼ（GPx）、カタラーゼ（CAT）、スーパーオキシドジスムターゼ（SOD）の活性およびチオール基量が低下した；肝臓と腎臓のマロンジアルデヒド（MDA）濃度が上昇した；RF+OLE群では、グルコース代謝異常はなく、肝臓と腎臓のGPx、CAT、SOD活性およびチオール基量も変化がなかった；また、肝臓のMDA濃度上昇は抑制されたが、腎臓では上昇した､などを報告している。
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To examine the effects of olive leave extracts on oxidative stress and glucose metabolism in liver and kidney of rats exposed to a 2.45 GHz electromagnetic field.
Four groups of rats were examined (n=6 per group): 1.) sham exposure group, daily injection of saline solution, 2.) sham exposure group, daily injection of olive leave extract (100 mg/kg body weight), 3.) exposure group, daily injection of saline solution and 4.) exposure group, daily injection of olive leave extract (100 mg/kg body weight).
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
2.45 GHz
ばく露時間:
1 hour/day for 21 consecutive days
|
- |
| 周波数 | 2.45 GHz |
|---|---|
| タイプ |
|
| ばく露時間 | 1 hour/day for 21 consecutive days |
No parameters are specified for this exposure.
In the liver and kidneys of exposed rats the enzyme activities of all superoxide dismutases, catalase and glutathione peroxidase as well as the level of thiol groups were significantly decreased compared to the sham exposed rats, while an administration of olive leave extract prevented these effects. Additionally, the lipid peroxidation was significantly increased in the liver and the kidneys of exposed rats in comparison to the control group. An administration of olive leave extract led to a signifcant decrease of the lipid peroxidation in the liver of exposed rats (but not in the kidneys) compared to exposed rats without olive leave extract.
Histopathological examinations of the liver of exposed rats revealed morphological abnormalities (e.g. hypertrophy, cell shape, steatosis) compared to the control group, while administration of olive leave extract prevented these effects.
The exposure of rats induced a diabetes-like status. In the exposure group, 20 minutes after the injection of glucose solution, blood glucose levels were significantly higher than in the sham exposure group, while administration of olive leave extract prevented the exposure related effect.
After exposure, various plasma parameters were changed compared to the control group: The level of total proteins, triglycerides, alanine transaminase, aspartate aminotransferase and creatinine was significantly increased while the level of uric acid was significantly decreased. In the exposure group with olive leave extract administration, the values for total proteins and creatinine were significantly reduced compared to the exposure group without olive leaf extract, while the level of uric acid was significantly increased.
The authors conclude that exposure to a 2.45 GHz signal could induce oxidative stress and a diabetes-like status in rats, while olive leave extract could attenuate these effects.
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