この研究は、ラットを用いた実験で、Wi-Fi（2.45 GHz）の電磁放射（EMR）がラットの喉頭気管粘膜に酸化ストレスを生じさせる可能性、さらに、そのような影響に対するメラトニンの保護作用の可能性を調べた。32匹の雄ラットを4群に等分した。すなわち対照群、擬似ばく露対照群、EMRばく露群、EMRばく露+メラトニン（10mg / kg /日）投与群である。EMRばく露は、60分/日で、28日間行われた。その結果、対照群および擬似ばく露対照群に比べ、EMRばく露群の喉頭気管粘膜の脂質過酸化レベルは有意に高かった；EMRばく露+メラトニン投与群の脂質過酸化レベルは、EMRばく露群に比べ、有意に低かった；対照群および擬似ばく露対照群に比べ、EMRばく露群のグルタチオンペルオキシダーゼの活性は低かったが、EMRばく露+メラトニン投与群では有意に増加した；喉頭気管粘膜におけるグルタチオンレベル低下は4群間で差がなかった、と報告している。
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To investigate the possible protective role of melatonin on oxidative stress generated by exposure to a WiFi-signal in rats.
Four groups (n=8 per group) were examined: 1.) cage control, 2.) sham exposure + saline injection. 3.) exposure and 4.) exposure + melatonin injection.
| 周波数 | 2,450 MHz |
|---|---|
| タイプ |
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| 波形 |
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| ばく露時間 | continuous for 60 min/d for 30 days (28 days? different indications in the article) |
| Modulation type | pulsed |
|---|---|
| Repetition frequency | 217 Hz |
| ばく露の発生源／構造 | |
|---|---|
| Distance between exposed object and exposure source | 1 m |
| チャンバの詳細 | exposure system was organized with a special cylindrical strainer which is appropriate for exposure condition and physical size of one rat (length 15 cm, diameter 5 cm), noses of rats were positioned in close contact to the antenna (according to a table in the article: distance between head and antenna 1 m (?)) and the tube was ventilated from head to tail to decrease stress, 8 rats (Figure shows 6 rats (?)) exposed at the same time |
| ばく露装置の詳細 | whole exposure system was kept in a Faraday cage |
| Sham exposure | A sham exposure was conducted. |
In the exposed group, the amount of lipid peroxidation was significantly increased compared to the cage control and the sham exposed group, while an administration of melatonin prevented this effect. No differences in the level of reduced glutathione were found between the groups. The enzyme activity of the glutathione peroxidase was lower (not significantly) in the exposed group than in the cage control and the sham exposure group. However, in the exposure group with melatonin administration, the enzyme activity of the glutathione peroxidase was significantly increased compared to the exposure group without melatonin administration.
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