この研究は、無線周波(RF)電磁界ばく露によるラットの脳組織及び血清中の酸化ストレスを調べた動物実験である。雄のWistarラット66匹を3等分し、第1群は900MHz、全身平均の比吸収率(SAR)1.08W/kgのRFに1時間/日、3週間ばく露した。第2群は第1群と同じRFに加えて、ニンニク粉末を溶かした生理食塩水を、体重1kgあたり500mg/日、3週間にわたって経口投与した。第3群は対照群とした。その結果、RFばく露群の脳組織ではマロンジアルデヒド(MDA)および高度酸化タンパク質産物(AOPP)の増加が認められた;ニンニク投与群では、RFばく露によるMDA及びAOPPへの影響が低減した;一酸化窒素(NO)のレベルには有意差は認められなかった;脳内でパラオキソナーゼは検出されなかった;RFばく露群の血清中ではNOレベルの有意な上昇が認められた;ニンニク投与では、RFばく露によるNOレベル上昇に影響しなかった、と報告している。
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To evaluate the oxidative stress in the brain tissue and serum of rats exposed to a radiofrequency electromagnetic field and the potential protective effect of garlic.
Three groups of rats were examined (n=22 per group): 1.) sham exposure, 2.) exposure and 3.) exposure + 500 mg/kg/day garlic.
Rats were divided into the following three groups: i) sham exposure ii) exposure iii) exposure + daily treatment with 500 mg/kg body weight garlic extract
周波数 | 850–950 MHz |
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タイプ |
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ばく露時間 | continuous for 1 h/day for 3 weeks |
ばく露の発生源/構造 |
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Distance between exposed object and exposure source | 4 cm |
チャンバの詳細 | 11 rats were simultanously exposed in a pie cage restrainer (for 12 rats) with an air hole |
ばく露装置の詳細 | monopole antenna was placed in the center of the pie cage restrainer; constrainers positioned radially around a 20 cm high antenna; distance between antenna and rat head: ca. 4 cm |
Sham exposure | A sham exposure was conducted. |
The serum nitric oxide levels were significantly increased in the exposed groups with and without garlic compared to the sham exposed group, but no significant difference was found between both exposure groups.
In the brain homogenates of the exposed group without garlic, the levels of malondialdehyde and the protein oxidation were significantly increased compared to the sham exposed group. An administration of garlic diminished these effects. Hence, no difference between the sham exposed group and the exposed group with garlic was observed in the brain tissue.
The authors conclude that exposure to a radiofrequency electromagnetic field of 900 MHz increased oxidative stress in rat brain and serum and that this effect was blocked in the brain by an administration of garlic.
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