研究のタイプ: 医学／生物学の研究 (experimental study)

[抗酸化酵素および肝機能検査項目に対する無線周波電磁界ばく露の影響] med./bio.

Radiofrequency electromagnetic field exposure effects on antioxidant enzymes and liver function tests

著者: Kumari K, Ramovatar M, Kumar S, Paulraj R, Verma NH, Kavindra Kumar K
掲載誌: International Journal of Life Sciences 2012; 1 (3): 233-239
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この研究は、ウィスター雄ラット（70日齢）を用いて、肝臓の酸化状態に対するマイクロ波電磁界（MW；2.45GHz）ばく露の影響を調べた。ばく露群、擬似ばく露群（各群n=6）は、1日2時間、35日間のばく露（擬似ばく露）を受けた。
影響評価項目として、グルタチオンペルオキシダーゼ（GPx）・スーパーオキシドジスムターゼ（SOD）・カタラーゼ（CAT）の活性、マロンジアルデヒド（MDA）濃度、肝機能に関する血清生化学パラメータを測定した。その結果、ばく露群では、擬似ばく露群に比べ、GPxおよびSODのレベルは低下し、CATレベルは上昇した；ばく露群では、擬似ばく露群に比べ、MDAレベルが上昇し、肝機能に関する血清生化学パラメータの変化が観察された、と報告している。

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研究目的（著者による）

To examine the influence of exposure to microwaves (2.45 GHz) or to the radiofrequency field of a mobile phone (900 MHz) on the oxidative status of the liver and further liver values in rats.

詳細情報

In the first experiment, rats were exposed (n=6) or sham exposed (n=6) to microwaves (2.45 GHz). In the second experiment, rats were exposed to the radiofrequency field of a mobile phone (900 MHz) (remark EMF-Portal: in the second experiment, no information was given about number of animals and treatment of control animals).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
ばく露時間: continuous for 2 hours/day for 35 days
ばく露2: 900 MHz
Modulation type: pulsed
ばく露時間: intermittend for 2 hours/day for 35 days
-

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 2 hours/day for 35 days
Modulation
Modulation type cf. additional information
Additional information

50 Hz modulation frequency
ばく露装置
ばく露の発生源／構造
チャンバの詳細 plexiglas cage with ventilation holes of 1 cm diameter
ばく露装置の詳細 exposure cage with animals was kept in an anechoic chamber; a microwave oven was used as exposure source connected to a 40 db attenuation and a horn antenna; animals were facing the horn antenna; temperature was maintained at 25-27°C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.15 W/kg - 推定値 whole body -
電力密度 0.22 mW/cm² - 測定値 - -
電力 1,080 W - - - input power
電力 700 W - - - output power

ばく露2

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittend for 2 hours/day for 35 days
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
チャンバの詳細 plexiglas cage with ventilation holes of 1 cm diameter in which rats were restricted (mobility 1-2 cm) during exposure
ばく露装置の詳細 exposure cage with animals was kept in an anechoic chamber; GSM mobile phones were kept on the top of the cage in such a configuration that there was preferential emissions towards the animals in the cage; every cage was attached with a seperate mobile phone; cell phone was in standby; calls lasted 1 min (no information given how many calls in the two hours); cell phones were in silent mode without vibration
パラメータ

No parameters are specified for this exposure.

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • liver
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Rats exposed to microwaves (2.45 GHz) or to the radiofrequency field of a mobile phone (900 MHz) showed significantly decreased enzyme activities of the glutathione peroxidase and the superoxide dismutase when compared to the control, while the enzyme activity of the catalase and the lipid peroxidation were significantly increased.
Additionally, all liver values in the serum of exposed rats (microwave or mobile phone) were significantly increased in comparison to the control group.
The authors conclude that exposure to microwaves (2.45 GHz) or to the radiofrequency field of a mobile phone (900 MHz) could lead to oxidative stress in the liver and to increased liver values in rats.

研究の種別:

研究助成

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