この研究は、900 MHz携帯電話電磁放射(EMR)への長期ばく露をラットに与え、酸化的ストレスを誘導するか否か、さらに、カフェ酸フェネチルエステル(CAPE:フラボノイド様物質)がEMR誘導性の腎障害から腎組織を保護する役割を持つか否かを調べた。スーパーオキシドや一酸化窒素(NO)などのROS(酸化的ストレスによる腎障害誘発の指標)、マロンジアルデヒド(MDA、脂質過酸化の指標)、尿中N-アセチル-ベータ-D-グルコサミニダーゼ(NAG、腎尿細管損傷のマーカー)のレベルを測定した。腎組織のスーパーオキシドジスムターゼ(SOD)、カタラーゼ(CAT)、およびグルタチオンペルオキシダーゼ(GSH-Px)の活性を測定し、抗酸化状態の変化を評価した。実験ではラットを次の4群に分けた(各n = 10): i)対照群(ストレスおよびEMRなし)、ii)擬似ばく露群、iii)900MHz EMRばく露群、iv)900 MHz EMRばく露+ CAPE処置(EMR + CAPE群)。 その結果、EMRばく露群では、腎組織のMDA、NOレベルおよび尿中NAGレベルが有意に上昇し、腎組織のSOD、CAT、およびGSH-Pxの活性は低下した;CAPE処置はこれらの影響を有意に逆転させた、と報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
To study long-term applied 900 MHz emitting mobile phone-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of CAPE (caffeic acid phenethyl ester) on kidney tissue against the possible electromagnetic irradiation-induced renal impairment in rats.
Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. It was found to be a potent free radical scavenger and antioxidant.
ROS such as superoxide and nitric oxide may contribute to the pathophysiology of electromagnetic irradiation-induced renal impairment.
周波数 | 900 MHz |
---|---|
タイプ |
|
ばく露時間 | repeated daily exposure, 30 min/day for 3 months |
Modulation type | pulsed |
---|
ばく露の発生源/構造 | |
---|---|
チャンバの詳細 | A special exposure device with six exposure antennas was used. One exposure system consisted of a ventilated plastic tube cage (12 cm long x 5 cm in diameter) and a half-wave dipole antenna. |
ばく露装置の詳細 | The whole body of the rat was positioned in close contact above the antenna. |
Additional information | Rats were allocated to four groups: control (without stress and EMR), sham exposed, EMR exposed, and EMR exposed + CAPE treated. CAPE was injected i.p. daily immediately before exposure. Sham exposed rats received isotonic saline solution instead. |
In the electromagnetic field exposed group, while tissue malondialdehyde, nitric oxide levels and urinary NAG levels increased, the activities of superoxide dismutase, catalase, and glutathione peroxidase in renal tissue were reduced. CAPE treatment reversed these effects as well.
In conclusion, the data demonstrate the role of oxidative mechanisms in 900 MHz mobile phone-induced renal tissue damage. CAPE, via its free radical scavenging and antioxidant properties, ameliorates oxidative renal damage. These data strongly suggest that CAPE exhibits a protective effect on mobile phone-induced and free radical mediated oxidative renal impairment in rats.
このウェブサイトはクッキー(Cookies)を使って、最善のブラウジングエクスペリエンスを提供しています。あなたがこのウェブサイトを継続して使用することで、私たちがクッキーを使用することを許可することになります。