この研究は、ラットにおける酸化的損傷のバイオマーカに対する超高周波電磁界放射（UHF EMR；950MHz）の影響を調べると同時に、肝臓の不飽和脂肪酸（UFA）濃度とカタラーゼ発現を確認した。妊娠したドブネズミ（Rattus norvegicus）をそれぞれ対照群、ばく露群（各群6匹）に分け、ばく露群は、出産までの21日間、SAR 1.3 - 1.0 W/kgに1日当たり1時間30分ばく露した。対照群、ばく露群から生まれた仔ラットを0、6、15、30日齢でそれぞれ6匹ずつ屠殺し、脂質、タンパク、DNAの損傷を、それぞれチオバルビツール酸反応性物質（TBARS）、カルボニル化タンパク、コメットアッセイで測定した。またそれぞれの日齢でのUFA濃度とカタラーゼ発現を測定した。ばく露群から生まれた仔ラットは同条件のばく露を継続したため、例えば30日齢ラットは51日間ばく露を受けたことになる。その結果、TBARSレベルおよびUFA濃度は、ばく露した後の0日齢で低かった；カルボニル化タンパクの蓄積量は、どの日齢でも、対照群とばく露群で有意差がなかった；DNA損傷は、15、30日齢で、対照群とばく露群で差が見られた；カタラーゼ発現は、ばく露した後の0日齢で低かった、と報告している。
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To investigate the effects of an exposure to a 950 MHz electromagnetic field on biochemical processes in the liver of young rats.
During pregnancy, dams were exposed (n=6) or sham exposed (n=6). From each group, 6 pups were sacrificed in the age of 0, 6, 15 and 30 days, respectively and examined. In the age of 15 and 30 days, only male rats were examined.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
950 MHz
ばく露時間:
30 minutes/day for 21 days during pregnancy
neonatal rats
|
|
|
ばく露2:
950 MHz
ばく露時間:
30 minutes/day for 21 days during pregnancy and postnatal until an age of 6 days
6 day-old rats
|
|
|
ばく露3:
950 MHz
ばく露時間:
30 minutes/day for 21 days during pregnancy and postnatal until an age of 15 days
15 day-old rats
|
|
|
ばく露4:
950 MHz
ばく露時間:
30 minutes/day for 21 days during pregnancy and postnatal until an age of 30 days
30 day-old rats
|
| 周波数 | 950 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 30 minutes/day for 21 days during pregnancy |
| Additional information | neonatal rats |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 11 cm |
| ばく露装置の詳細 | cages were placed inside an aluminium Faraday cage (101.5 x 64.0 x 38 cm); antenna was configured for vertical polarization |
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 950 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 30 minutes/day for 21 days during pregnancy and postnatal until an age of 6 days |
| Additional information | 6 day-old rats |
| ばく露の発生源／構造 |
|
|---|
| 周波数 | 950 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 30 minutes/day for 21 days during pregnancy and postnatal until an age of 15 days |
| Additional information | 15 day-old rats |
| ばく露の発生源／構造 |
|
|---|
| 周波数 | 950 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 30 minutes/day for 21 days during pregnancy and postnatal until an age of 30 days |
| Additional information | 30 day-old rats |
| ばく露の発生源／構造 |
|
|---|
Neonatal rats exposed in utero had a significanty decreased body weight, significantly decreased levels of catalase and significant lower lipid peroxidation values compared to neonatal rats from the control group. No significant differences in the body weight, the levels of catalase and the lipid peroxidation were observed after 6, 15 or 30 days between the groups.
No differences occurred in the level of protein oxidation between exposed and sham exposed rats.
The level of fatty acids was significantly decreased in exposed rats in comparison to sham exposed rats (Remark EMF-Portal: information about age of rats not given in this context).
15 and 30 day-old rats showed significant differences regarding DNA damage. In the age of 15 days, in the exposed rats, the number of DNA strand breaks was significantly lower compared to the control group, while it was significantly higher in the age of 30 days.
The data indicate that exposure to 950 MHz electromagnetic fields could have induced some biochemical changes in the liver of young rats.
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