Liver antioxidant stores protect the brain from electromagnetic radiation (900 and 1800 MHz)-induced oxidative stress in rats during pregnancy and the development of offspring
著者:
Cetin H, Naziroglu M, Celik O, Yuksel M, Pastaci N, Ozkaya MO
掲載誌: J Matern Fetal Neonatal Med 2014; 27 (18): 1915-1921
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研究目的（著者による）
To investigate the effects of electromagnetic fields emitted by mobile phones on oxidative stress in the brain and liver of young rats.
詳細情報
32 pregnant rats were equally divided into three groups: 1.) control group, 2.) exposure to a 900 MHz electromagnetic field and 3.) exposure to a 1800 MHz electromagnetic field. From each group 24 male pups were chosen and subjected to the same exposure condition as the respective dam. The young rats were killed and examined in the age of 4, 5, and 6 weeks (n=8 per group and time point).
影響評価項目
oxidative stress and concentration of diverse chemical elements (see methods) in brain and liver of young rats
Distance between exposed object and exposure source
1 cm
ばく露装置の詳細
generator was equipped with a half-wave dipole antenna system; exposure system was kept in a specific room with plastic furniture to prevent possible radiation reflection; walls of the room were completely covered by chromium-nickel metals for protection from possible outside telemetric exposure; as shown by a picture, rats were exposed simultaneously in plastic cylinders with its heads to the antenna
Additional information
contradictory information given about control group: in one sentence it is stated that control group rats were placed in a cylindrical container with the radiofrequency source switched off; another sentence says that the control animals were kept in their cage without any treatment or restraint of any kind.
oxidative stress: lipid peroxidation (via thiobarbituric acid-reactive substances), glutathione content, enzyme activity of the glutathione peroxidase, levels of vitamin A, vitamin E and beta-carotene in brain and liver tissue (spectrophotometry); concentration of chemical elements (chromium, copper, iron, magnesium, manganese, selenium, and zinc) in brain tissue (atomic absorption spectrophotometry)
Malformation or prenatal death was not observed during the experiment. In the liver and brain of exposed rats (900 MHz and 1800 MHz), the enzyme activity of the glutathione peroxidase (in 4- and 5-week-old rats) was significantly decreased compared to the control group. In the brain of both exposure groups, the level of vitamin A (in 4-, 5-, and 6-week-old rats) and the level of beta-carotene (in 4- and 5-week-old rats) were significantly increased when compared to the control animals. In the liver of exposed rats, the lipid peroxidation (in 4-, 5-, and 6-week old rats) was significant increased in comparison to the control, while the levels of vitamin A and beta-carotene were significantly decreased (in 4-, 5-, and 6-week old rats). In 4-, 5-, and 6-week-old rats, the exposed groups showed significant increases regarding iron levels compared to the control, while the selenium concentration was significantly decreased in 6-week-old exposed rats. The authors conclude that electromagnetic fields emitted by mobile phones could be a cause of oxidative brain and liver injuries in young rats.
