Medizinische/biologische Studie (experimentelle Studie)

Exposure to extremely low frequency magnetic fields suppresses x-ray-induced transformation in mouse C3H10T1/2 cells med./bio.

[Exposition bei extrem niederfrequenten Magnetfeldern unterdrückt die durch Röntgenstrahlen induzierteTransformation in C3H10T1/2-Zellen der Maus]

Von: Miyakoshi J, Yoshida M, Yaguchi H, Ding GR

Veröffentlicht in: Biochem Biophys Res Commun 2000; 271 (2): 323-327

Diese Studie wurde durchgeführt, um die Wirkungen eines extrem niederfrequenten Magnetfeldes auf die Zelltransformation bei Zellen der Maus in vitro zu untersuchen.

Exposition	Parameter
Exposition 1: 60 Hz Expositionsdauer: 24 h	magnetische Flussdichte: 400 mT Maximum (5, 50, 400mT)
Exposition 2: 60 Hz Expositionsdauer: 6 Wochen	magnetische Flussdichte: 5 mT

Frequenz	60 Hz
Typ	Magnetfeld
Expositionsdauer	24 h
Zusatzinfo	experiments were performed: i) with only EMF exposure ii) with X-rays and EMF exposure iii) with EMF exposure plus TPA iv) with X-rays, EMF exposure and TPA

Expositionsquelle	see Miyakoshi et. al. and Yaguchi et. al.

Messgröße	Wert	Typ	Methode	Masse	Bemerkungen
magnetische Flussdichte	400 mT	Maximum	-	-	5, 50, 400mT

X-ray irradiation with 3 Gy

Frequenz	60 Hz
Typ	Magnetfeld
Expositionsdauer	6 Wochen
Zusatzinfo	experiments were performed with: i) only EMF exposure ii) only X-ray irradiation iii) X-ray irradiation and EMF exposure iv) neither x-rays nor EMF exposure

Expositionsquelle	gleicher Aufbau wie Exposition 1
Schein-Exposition	Eine Schein-Exposition wurde durchgeführt.

Messgröße	Wert	Typ	Methode	Masse	Bemerkungen
magnetische Flussdichte	5 mT	-	-	-	-

Yaguchi H et al. (1999): Effect of high-density extremely low frequency magnetic field on sister chromatid exchanges in mouse m5S cells
Miyakoshi J et al. (1996): Exposure to magnetic field (5 mT at 60 Hz) does not affect cell growth and c-myc gene expression
Miyakoshi J et al. (1994): A newly designed experimental system for exposure of mammalian cells to extremely low frequency magnetic fields

Exponiertes System:

Untersuchtes System:

Untersuchungszeitpunkt:

Studienmerkmale:

Ministry of Education, Culture, Sports, Science and Technology, Japan
Research for Future Program, Japan Society for the Promotion of Science (JSPS), Japan

Lee HJ et al. (2012): Combined effects of 60 Hz electromagnetic field exposure with various stress factors on cellular transformation in NIH3T3 cells
Jin M et al. (2000): ERK1/2 phosphorylation, induced by electromagnetic fields, diminishes during neoplastic transformation
Snawder JE et al. (1999): Effect of magnetic field exposure on anchorage-independent growth of a promoter-sensitive mouse epidermal cell line (JB6)
Saffer JD et al. (1997): Power frequency magnetic fields do not contribute to transformation of JB6 cells
Harrison GH et al. (1997): Kinetics of gene expression following exposure to 60 Hz, 2 mT magnetic fields in three human cell lines
West RW et al. (1996): Anchorage-independent growth with JB6 cells exposed to 60 Hz magnetic fields at several flux densities
Balcer-Kubiczek EK et al. (1996): Rodent cell transformation and immediate early gene expression following 60-Hz magnetic field exposure
West RW et al. (1994): Enhancement of anchorage-independent growth in JB6 cells exposed to 60 hertz magnetic fields
Cain CD et al. (1993): 60 Hz magnetic field acts as co-promoter in focus formation of C3H/10T1/2 cells