Studientyp:
Medizinische/biologische Studie
(experimentelle Studie)
Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent
med./bio.
[Mobilfkunk-Befeldung verursacht Veränderungen in der Gen- und Protein-Expression in humanen Endothel-Zelllinien und die Reaktion scheint Genom- und Proteom-abhängig zu sein]
Die Veränderungen der Genexpression wurden in drei Experimenten untersucht und die Untersuchung der Protein-Expressions-Veränderungen wurde in 10 Experimenten wiederholt. Die Arbeit ist Teil des REFLEX-Projektes (Risk Evaluation of Potential Environmental Hazards From Low Energy Electromagnetic Field Exposure Using Sensitive in vitro Methods), gefördert durch die Europäische Union.
Leszczynski D et al.
(2002):
Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer- and blood-brain barrier-related effects
Die Ergebnisse zeigten, dass die Gen- und Protein-Expression in beiden Zelllinien in Reaktion auf die Handy-Befeldung verändert war. Darüber hinaus wurden in beiden Zelllinien durch dieselbe Exposition verschiedene Gene und verschiedene Proteine beeinflusst. Dies deutet darauf hin, dass unter diesen experimentellen Bedingungen die Zell-Reaktionen Genom- und Proteom-abhängig sein könnten.
STUK (Radiation and Nuclear Safety Authority), Helsinki, Finland
Tekes (National Technology Agency), Finland
Themenverwandte Artikel
Valbonesi P et al.
(2014):
Effects of the exposure to intermittent 1.8 GHz radio frequency electromagnetic fields on HSP70 expression and MAPK signaling pathways in PC12 cells
Zhijian C et al.
(2013):
Studying the protein expression in human B lymphoblastoid cells exposed to 1.8-GHz (GSM) radiofrequency radiation (RFR) with protein microarray
Bourthoumieu S et al.
(2013):
Study of p53 expression and post-transcriptional modifications after GSM-900 radiofrequency exposure of human amniotic cells
Fragopoulou AF et al.
(2012):
Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation
Sakurai T et al.
(2011):
Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields
Roux D et al.
(2011):
Human keratinocytes in culture exhibit no response when exposed to short duration, low amplitude, high frequency (900 MHz) electromagnetic fields in a reverberation chamber
Nylund R et al.
(2010):
Analysis of proteome response to the mobile phone radiation in two types of human primary endothelial cells
Kim KB et al.
(2010):
Two-dimensional electrophoretic analysis of radio-frequency radiation-exposed MCF7 breast cancer cells
Sekijima M et al.
(2010):
2-GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells
Gerner C et al.
(2010):
Increased protein synthesis by cells exposed to a 1,800-MHz radio-frequency mobile phone electromagnetic field, detected by proteome profiling
Nylund R et al.
(2009):
Proteomic Analysis of the Response of Human Endothelial Cell Line EA.hy926 to 1800 GSM Mobile Phone Radiation
Paparini A et al.
(2008):
No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal
Franzellitti S et al.
(2008):
HSP70 expression in human trophoblast cells exposed to different 1.8 Ghz mobile phone signals
Nittby H et al.
(2008):
Exposure to radiation from global system for mobile communications at 1,800 MHz significantly changes gene expression in rat hippocampus and cortex
Chauhan V et al.
(2007):
Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field
Friedman J et al.
(2007):
Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies
Zhao R et al.
(2007):
Studying gene expression profile of rat neuron exposed to 1800 MHz radiofrequency electromagnetic fields with cDNA microassay
Chauhan V et al.
(2006):
Analysis of proto-oncogene and heat-shock protein gene expression in human derived cell-lines exposed in vitro to an intermittent 1.9 GHz pulse-modulated radiofrequency field
Whitehead TD et al.
(2006):
The number of genes changing expression after chronic exposure to Code Division Multiple Access or Frequency DMA radiofrequency radiation does not exceed the false-positive rate
Leszczynski D et al.
(2006):
Questions and answers concerning applicability of proteomics and transcriptomics in EMF research
Zeng Q et al.
(2006):
Effects of global system for mobile communications 1800 MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells
Qutob SS et al.
(2006):
Microarray gene expression profiling of a human glioblastoma cell line exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field
Belyaev IY et al.
(2006):
Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation
Nikolova T et al.
(2005):
Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells
Czyz J et al.
(2004):
High frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53-deficient embryonic stem cells
Nylund R et al.
(2004):
Proteomics analysis of human endothelial cell line EA.hy926 after exposure to GSM 900 radiation
Leszczynski D et al.
(2004):
Applicability of discovery science approach to determine biological effects of mobile phone radiation
Leszczynski D et al.
(2002):
Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer- and blood-brain barrier-related effects
Pacini S et al.
(2002):
Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts
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