この研究は、先行研究を背景としている。無線周波電磁界の血液脳関門（BBB）への影響はインビトロあるいは動物での研究がほとんどの中で、1件だけヒトでの研究があり、マイクロ波ばく露による血清トランスサイレンチ（TTR）の有意な上昇を示しているという。研究デザインを改良してこの先行研究の再現を試みた。単ブラインド化無作為化カウンターバランス試験で、健康な被験者（n=24：18-30歳）は、3つのばく露条件（10g平均SAR値：2W/kg、0.2W/kg、および擬似ばく露）のマイクロ波（890MHzの携帯電話様の信号）全てのばく露セッションを受けた。それぞれのばく露の前後の血清パラメータを分析した。その結果、マイクロ波ばく露後にフォローアップした2時間以内では、先行研究が報告したマイクロ波ばく露のBBBに対する急性影響は確認されなかった、と報告している。
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The effects of exposure to a 890 MHz electromagnetic field (GSM) on the human blood brain barrier permeability should be investigated.
The present study should follow up on previous studies by the authors on the human blood brain barrier permeability (Söderqvist et al. 2009a, Söderqvist et al. 2009b, Söderqvist et al. 2009c) using a better study design.
A total of 24 subjects (12 men and 12 women) participated in 3 sessions with at least one week in between. During each session, 1 hour of exposure was conducted in a randomized counter balanced order under the following conditions: 1) exposure with SAR of 2 W/kg, 2) exposure with SAR of 0.2 W/kg, 3) sham exposure. Each participant acted as his or her own control and blood samples were taken: a) at arrival, b) after 30 min of rest, c) after 1 h of rest/start of exposure, d) immediately after exposure, e) 1 h after the end exposure; f) 2 h after the end of exposure.
| 周波数 | 890 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 1 hour |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 4 cm |
| チャンバの詳細 | room was shielded by a specially made baldachin (250 x 210 x 230 cm); inside, special radiofrequency-absorbing material (eccosorb) was mounted to avoid reflection of waves |
| ばく露装置の詳細 | the signal from a GSM test phone (Ericsson GH 337) was fed to an indoor base station antenna; two identical antennas were used, one mounted on each side of the participant's head at a distance of 4 cm from the ear, but only the right antenna was used; subjects were seated in a reclining chair in front of a LCD computer screen to watch a DVD during the session |
| Sham exposure | A sham exposure was conducted. |
| Additional information | trials were carried out in a room with low-frequency electric, magnetic and radiofrequency background fields low enough to be considered negligible |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 2 W/kg | average over mass | - | 10 g | - |
| 周波数 | 890 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 1 hour |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 4 cm |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 0.2 W/kg | average over mass | - | 10 g | - |
Statistically significant changes in transthyretin and beta-trace protein levels were found over the course of time in each exposure condition (SAR of 2 W/kg, 0.2 W/kg and sham exposure). However, no significant differences were found between exposure conditions with and without regard to the time of blood sampling.
The authors conclude that exposure to a 890 MHz electromagnetic field (GSM) did not show any effects on the human blood brain barrier permeability.
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