この実験研究は、妊娠初期から出産予定日の1日前までWiFi信号の電磁界（中心周波数帯2450MHz）に子宮内ばく露したマウス胎仔の出生後のT細胞の発達と機能への影響を調べた。妊娠準備のできた雌マウスをそれぞれ16匹ずつ、電磁界ばく露群、擬似ばく露群、ケージ対照群として交配させたのち、ばく露群には1日2時間、SAR4 W/kgの電磁界ばく露を与えた（2個のTEMセルに8匹ずつ入れた。8匹のばく露は同等であることをモデル計算で確認した）。各群の新生仔は全て同じ環境で生育させ、同じ母マウスから生まれた仔マウス雌雄各1匹を5週目ないし26週目に屠殺して、免疫学的分析を行った。その結果、全ての群において胸腺細胞の細胞数・表現型・増殖に何も変化はなく、脾臓の細胞数・CD4/CD8比・T細胞増殖・サイトカイン産生にもばく露の影響は見られず、また雌と雄、5週目と26週目でも同じ結果であったと報告している。
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To study the effects of prenatal (in utero) exposure in mice to WiFi signals on development and function of immune cells.
The development of the immune system begins during embryogenesis, continues through fetal life, and is followed by a postnatal maturation period lasting several weeks in mice. All these phases are highly susceptible to the action of several noxious agents.
Pregnant mice were divided into three groups (n=16 per group): 1.) cage control, 2.) sham exposed and 3.) exposed. Exposure started five days after mating and ended one day before the expected delivery. The offspring was examined at the age of 5 weeks and 26 weeks. At every time point, one male and one female pup from each dam were sacrificed to perform immunological analyses.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
2,451–2,473 MHz
Modulation type:
pulsed
ばく露時間:
continuous for 2 h/day on 14 consecutive days (starting 5 days after mating, ending 1 day before expected delivery)
|
|
| Modulation type | pulsed |
|---|---|
| Pulse type | rectangular |
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | mice restrained in transparent cylindrical polymethyl-methacrylate jigs with the posterior part on the side of the field origin and maintained with the caudal axis parallel to the direction of field propagation |
| ばく露装置の詳細 | two identical 120 cm long TEM cells; signal generated by commercial WiFi access point connected to a notebook via LAN and communicating with a PC using single channel transmission with channel 11; signal directly taken from the access point; daily clockwise rotation of the eight pregnant mice inside each of the two TEM cells used; temperature regulated; mice positioned at the two areas of maximum E-field (4 mice/area), two above and two under each of the two septums |
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 4 W/kg | average over mass | 測定値および計算値 | whole body | - |
No effects due to exposure to WiFi signals during pregnancy on mating success, number of newborns per dam and body weight of offspring at birth were found.
The results showed no exposure-related effects on the number and proliferation as well as on the cell differentiation in the thymus and the spleen at both time points. Observed differences were due to age and/or gender.
In summary, these results do not support the hypothesis that in utero-exposure to a WiFi signal has detrimental effects on the development of immune cells in mice.
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