研究のタイプ: 医学／生物学の研究 (experimental study)

[子宮内でWi-Fiシグナルにばく露された幼若ラットの脳におけるグリオーシスおよびアポトーシスのイン・サイチュ検出] med./bio.

In situ detection of gliosis and apoptosis in the brains of young rats exposed in utero to a Wi-Fi signal

著者: Ait-Aissa S, Billaudel B, Poulletier de Gannes F, Hurtier A, Haro E, Taxile M, Ruffie G, Athane A, Veyret B, Lagroye I
掲載誌: CR physique 2010; 11 (9-10): 592-601
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この研究は、ラットを用いた実験で、Wi-Fi信号への子宮内ばく露と、それに引き続いて出生後ばく露を受けた仔ラットの脳組織を調査した。妊娠ラットに、自由行動ができる反射反響室内で、妊娠の最後の2週間、5日/週で毎日、全身平均SARが0、0.08、0.4、および4 W / kgの条件で、Wi-Fi信号への全身ばく露または擬似ばく露を与えた。この子宮内ばく露後に出生した仔ラットを2群（ばく露群と擬似ばく露群）に分け、ばく露群には、出生後5週間、子宮内ばく露と同じ条件でばく露を与えた。このばく露終了後に、いくつかの脳領域において、グリオーシス（神経組織での星状膠細胞の増生）およびアポトーシス細胞を探索した。その結果、ばく露群と擬似ばく露群との比較で、脳領域でのグリオーシスおよびアポトーシスに有意差は見られず、子宮内および出生後のWi-Fiへのばく露は若いラットの脳に損傷を与えなかったことが示唆された、と報告している。

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研究目的（著者による）

To assess whether exposure to a WiFi signal had an impact on the central nervous system of young rats exposed in utero and during early life.

詳細情報

60 pregnant rats were exposed or sham-exposed to a WiFi signal at different SAR values during the last two weeks of gestation (cage control, sham exposure group and three exposure groups à 12 animals). Following the in utero exposure, the pups were divided into two groups: one group continued exposure for 5 weeks after birth (together with the dams and three pups per litter) and the rest of the litter (exposed only in utero) was kept in the animal facility for 5 weeks (n=3-15 per litter). One pup per litter was investigated.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
ばく露時間: continuous for 2 h/day, 5 days/week for 2 weeks (day 6 to day 21 of gestation) or 7 weeks (day 6 to day 21 of gestation + 5 weeks after birth)
  • SAR: 0.08 W/kg (for the dams)
  • SAR: 0.4 W/kg (for the dams)
  • SAR: 4 W/kg (for the dams)
  • SAR: 9 W/kg peak (whole body) (9 ± 3 W/kg for the pups)

General information

Rats were divided into five groups: i) cage control ii) sham exposure iii) whole body exposure at 0.08 W/kg (public exposure limit) iv) whole body exposure at 0.4 W/kg (professional exposure limit) v) whole body exposure at 4 W/kg (ICNIRP critical level)

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 h/day, 5 days/week for 2 weeks (day 6 to day 21 of gestation) or 7 weeks (day 6 to day 21 of gestation + 5 weeks after birth)
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 150 cm x 150 cm x 150 cm cubic reverberation chamber with six dipole antennas, activated at random and three paddles for mode stirring; animal cages placed in a 40 cm x 40 cm x 40 cm volume at the center of the chamber
Sham exposure A sham exposure was conducted.
Additional information Wi-Fi signal (IEEE 802.11 b/g) based on the "dialog" between two PCs equipped with Wi-Fi cards
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.08 W/kg - 計算値 whole body for the dams
SAR 0.4 W/kg - 計算値 whole body for the dams
SAR 4 W/kg - 計算値 whole body for the dams
SAR 9 W/kg peak 計算値 whole body 9 ± 3 W/kg for the pups

Reference articles

  • Wu T et al. (2010): [2.4GHzで動作する反響チャンバでの新生仔および若年のラットの全身ばく露評価]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Under these experimental conditions, whole body exposure in utero with and without extended postnatal exposure to a WiFi signal did not trigger persistent astroglia activation or did not induce apoptosis in the brains of young rats. These data suggest that prenatal exposure to WiFi has no deleterious effects on the integrity of the developing rat brain.

研究の種別:

研究助成

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