【背景と目的】1974-1986年に発表されたロシアとウクライナの文献は、５W/m2で2375MHzの連続波を30日間、全身ばく露は、ラット脳組織の抗原性の構造を破壊すると報告した。この作用がばく露された動物の自己免疫反応を引き起こすことを著者らは示唆した。さらに、ばく露ラットの血清を、無ばく露の妊娠10日のメスラットに注入すると、着床後の胚の死亡率増加と胎仔の体重減少が起きたことを報告した。これらの結果が前USSRのばく露限度値設定の根拠として使用されたので、現在のドシメトリ法と生物的手法を用いて、これらの研究の確認が必要である。【方法】遠方電磁界という条件下で、自由行動するラットへのばく露を行う新しいシステムを構築した。全身および脳での平均SARを計算した。【結果】ELISAテストおよび古典的な奇形学の検査項目を使用した全ての結果はネガティブであった。【結論】今回のばく露条件下（2450 MHz, CW, 7 h/day, 30 days, 0.16 W/kg 全身SAR）では、RFばく露は、重大な免疫および変性パラメータまたは出生前の発育にいかなる影響も与えなかった。
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To confirm previous data on effects of 2450 MHz microwave exposure on immunological processes and teratology in rats.
In a series of Russian and Ukrainian publications published from 1974-1986 (Vinogradov et al. 1974, Vinogradov et al. 1975, Shandala et al. 1983, Vinogradov et al. 1985, Vinogradov and Naumenko 1986, Shandala and Vinogradov 1982) it was reported that 30 day whole body exposure to radiofrequency irradiation (2375 MHz, 5 W/m², continuous wave) disrupted the antigenic structure of rat brain tissue. The authors suggested that this action caused an autoimmune response in exposed animals. Moreover, these studies reported that blood serum from irradiated rats injected into intact nonexposed female rats on the 10th day of pregnancy led to increased postimplantation embryo mortality and decreased fetus body weight and size.
Because the findings of these studies served in part as the basis for setting exposure limit values in the former USSR, it was deemed necessary to perform confirmation studies, using modern dosimetric and biological methods.
For immunological investigation blood of 48 rats (16 rats/group; sham exposure, exposure, cage control) was taken on days 7 (5 rats per group) and 14 (11 rats per group) after exposure.
For teratological experiments, blood sera of the 11 rats (14 days following exposure) were prepared. Sera from exposed and sham exposed rats were administered to two groups of female rats on the 10th day of pregnancy (20 rats/group). A third group of pregnant females received no treatment (control group).
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
2,450 MHz
Modulation type:
CW
ばく露時間:
continuous for 7 hr/day, 5 days/week, for 30 days
|
| 周波数 | 2,450 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| 偏波 |
|
| ばく露時間 | continuous for 7 hr/day, 5 days/week, for 30 days |
| Modulation type | CW |
|---|
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 2 m |
| ばく露装置の詳細 | 3 m x 3 m x 3 m anechoic chamber, inner walls coated with 30 cm thick carbon-loaded foam in a pyramidal shape, outer walls shielded with aluminum foil, antenna positioned at the ceiling and a ring with 16 compartments of 220 mm x 180 mm x 140 mm holding the rats placed on the absorbing floor |
All data, using ELISA and classic teratology endpoints, were negative. Under these exposure conditions (2450 MHz, CW, 7 h/day, 30 days, 0.16 W/kg whole body SAR), radiofrequency exposure had no influence on several immune and degenerative parameters or on prenatal development (this is in contrast to previous Soviet studies).
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