この研究は、マウス(抄録ではratとなっているが、本文ではICRマウスである)の海馬に対する低レベルの無線周波電磁界ばく露(835 MHz、SAR=1.6 W/kg、1日8時間、3ヵ月間ばく露)の影響を、免疫組織化学法によりカルビジンD28-Kのようなカルシウム結合タンパク(CB)及びグリア細胞繊維性酸性タンパク質(GFAP)に特異的な抗体について調べた。ばく露群、擬似ばく露群はそれぞれ10匹。その結果、ばく露群では、CBの免疫反応(IR)の低下が顕著であり、CAI領域の介在ニューロン及び錐体細胞の消失並びに顆粒細胞の消失を伴った;ばく露群では、海馬のGFAP IRが上昇した;TUNEL解析により、アポトーシス細胞がCA1領域、CA3領域並びに海馬歯状回において検出された、などの知見を報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
To study the effect of 835 MHz radiofrequency exposure on mice hippocampus after three months of exposure.
Calcium binding proteins like calbindin D28k are responsible for the maintaining and controlling calcium homeostasis. Increased expression of glial fibrillary acidic protein (GFAP) has often been recognized in brain injury. Disturbance of Ca2+ homeostasis has been known to be Iinked with increase of GFAP immunoreactivity after brain injury.
20 mice were divided into two groups: sham exposure group and exposure group.
周波数 | 835 MHz |
---|---|
タイプ |
|
ばく露時間 | continuous for 8 hr/day for 3 months |
ばく露の発生源/構造 |
|
---|---|
Sham exposure | A sham exposure was conducted. |
The data showed a decrease in calbindin D28k immune reactivity in the exposed group with loss of interneurons and pyramidal cells in CA1 area and loss of granule cells. Also, an overall increase in GFAP immune reactivity was observed in the hippocampus of exposed mice.
Apoptotic cells were detected in different areas of the hippocampus (CA1, CA3 and dentate gyrus) of exposed mice, which reflects that chronic radiofrequency exposure may affect the cell viability. In addition, the increase of GFAP immunoreactivity due to radiofrequency exposure could be related with reactive astrocytosis (abnormal increase in the number of astrocytes).
The data suggest that the decrease of calbindin D28k immune reactivity, accompanying apoptosis and increase of GFAP immune reactivity might be morphological parameters in the hippocampus damage.
このウェブサイトはクッキー(Cookies)を使って、最善のブラウジングエクスペリエンスを提供しています。あなたがこのウェブサイトを継続して使用することで、私たちがクッキーを使用することを許可することになります。