研究のタイプ: 医学／生物学の研究 (experimental study)

[Jurkat細胞における活性酸素種の形成はUMTS1950 MHz放射ばく露によって、あるいは鉄イオンとの複合ばく露によって強化されない] med./bio.

Reactive oxygen species formation is not enhanced by exposure to UMTS 1950 MHz radiation and co-exposure to ferrous ions in Jurkat cells

著者: Brescia F, Sarti M, Massa R, Calabrese ML, Sannino A, Scarfi MR
掲載誌: Bioelectromagnetics 2009; 30 (7): 525-535
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この論文は、ヒトのリンパ芽球培養細胞に無線周波電磁界の単独ばく露、あるいは鉄イオンと電磁界の]複合ばく露を与え、フローサイトメトリーにより活性酸素種の産生を計測した。ばく露した電磁界はUMTSシステムに用いられる1950MHzの信号で、SARは2.0 W/kg、5分から60分の短時間ばく露または24時間の長時間ばく露を行った。その結果、どのばく露条件においても活性酸素種の増加は見られなかったと報告している。

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研究目的（著者による）

To study cell viability and reactive oxygen species formation in human lymphoblastoid cells exposed to 1950 MHz, UMTS signal, for short (1 h) or long (24 h) exposure duration. To investigate if radiofrequency exposure may modify reactive oxygen species production induced by a well known oxidative stress inducer, co-exposures with ferrous ions (Fe2+, administered as iron sulfate FeSO4) were also carried out (concurrent or after radiofrequency exposure).

詳細情報

Ferrous ions act by producing a very reactive free radical, the hydroxyl radical (OH.). Positive controls were treated with iron sulfate for the same duration.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,950 MHz
ばく露時間: 5 min - 60 min or 24 h

General information

experiments were conducted under 4 different conditions: i) 5 min - 60 min RF only ii) 24 h RF only iii) 5 min - 60 min RF + FeSO4 iv) 24 h RF + FeSO4

ばく露1

主たる特性
周波数 1,950 MHz
タイプ
  • electromagnetic field
ばく露時間 5 min - 60 min or 24 h
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 rectangular short-circuited waveguide (109.2 mm x 54.6 mm x 500 mm) in TE10 mode; cell cultures placed on a plastic stand inside the waveguide; electric field parallel to the sample surface
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.5 W/kg - 計算値 - -
SAR 2 W/kg - 計算値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The data indicate that non-thermal radiofrequency exposures do not increase spontaneous reactive oxygen species formation in any of the experimental conditions investigated. Consistent with the lack of reactive oxygen species formation, no change in cell viability was found in radiofrequency exposed cells.
Similar results were obtained when co-exposures were considered: combined exposures to radiofrequency and iron sulfate (as stress-inducer) did not increase reactive oxygen species production induced by the chemical treatment alone.

研究の種別:

研究助成

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