この研究は、頭蓋内9L腫瘍モデルを用いて、携帯電話様の高周波(RF)電磁界ばく露が中枢神経系腫瘍の増殖に影響を与えるか否かを調べた。異なる数の9L神経膠肉腫細胞を移植されたFischer 344ラットに、835.62 MHz周波数変調連続波(FMCW)または847.74 MHz符号分割多元接続(CDMA)のRFばく露を与えた。公称スロット平均の脳内SARは0.75±0.25 W / kgであった。腫瘍細胞移植の4週間前から最長150日後まで、1日4時間、週5日、ばく露を実施した。擬似ばく露の場合、生存日数中央値および150日における生存割合は、グループ1(2〜10個移植)では、70日および27%、グループ2(11〜36個移植)では、52日および14%、グループ3(37〜100個移植)では、45日および0 %であった。CDMAまたはFMCWのばく露の場合も、同様の生存パラメータとなり、腫瘍細胞移植数別グループそれぞれの生存曲線の統計的比較においても、擬似ばく露との有意差はなかった、と報告している。
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To determine if exposure to a radiofrequency electromagnetic field similar to those used in cellular phone has any effects on the growth of a central nervous system tumor. The intracranial 9L (gliosarcoma cells) tumor model was used.
ばく露 | パラメータ |
---|---|
ばく露1:
835.26 MHz
ばく露時間:
repeated daily exposure, 4 h/day, 5 days/week, for up to 178 days
FMCW
|
|
ばく露2:
847.74 MHz
ばく露時間:
repeated daily exposure, 4 h/day, 5 days/week, for up to 178 days
CDMA
|
Rats were assigned randomly to one of three exposure groups that were injected in the brain with three different numbers of tumour cells.
周波数 | 835.26 MHz |
---|---|
タイプ |
|
ばく露時間 | repeated daily exposure, 4 h/day, 5 days/week, for up to 178 days |
Additional information | FMCW |
Modulation type | cf. additional information |
---|---|
Additional information |
FMCW |
ばく露の発生源/構造 | |
---|---|
チャンバの詳細 | RF field exposure was carried out in the "chamberettes" described in [Moros et al., 1998]. Each chamberette consisted of four carousels stacked vertically. In order to factor out possible confounders, the angular orientation of the carousel and the location (shelf and chamber) were varied every day according to a randomization schedule. |
ばく露装置の詳細 | Ten animals, each housed in a cylindrical restrainer, were placed on a carousel, equidistant from the central dipole antenna with their heads pointing towards the center. Sham-exposure carousels had no antenna. Larger restraint devices were used as the animals grew, in order to maintain the appropriate distance from the source. |
Sham exposure | A sham exposure was conducted. |
Additional information | Exposure of the animals started 4 weeks before and continued up to 150 days after the implantation of tumour cells. |
周波数 | 847.74 MHz |
---|---|
タイプ |
|
ばく露時間 | repeated daily exposure, 4 h/day, 5 days/week, for up to 178 days |
Additional information | CDMA |
Modulation type | cf. additional information |
---|---|
Additional information |
CDMA |
ばく露の発生源/構造 |
|
---|
Exposure under these conditions did not result in any differences in the growth of 9L glioma cells implanted in rats. The animals exposed to CDMA (code division multiple access) or FMCW (frequency modulated continuous wave) had similar survival parameters. Survival curves for the exposed groups showed no significant differences compared to sham-exposed controls.
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