研究のタイプ: 医学／生物学の研究 (experimental study)

[ラットの自然発病腫瘍発生への835.62 MHz FDMAまたは847.74 MHz CDMAラジオ周波数照射の慢性ばく露の影響] med./bio.

The Effect of Chronic Exposure to 835.62 MHz FDMA or 847.74 MHz CDMA Radiofrequency Radiation on the Incidence of Spontaneous Tumors in Rats

著者: LaRegina MC, Moros EG, Pickard WF, Straube WL, Baty J, Roti Roti JL
掲載誌: Radiat Res 2003; 160 (2): 143-151
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この研究は、携帯電話からの無線周波（RF）電磁界への慢性ばく露がF344ラットにおける自然発生的腫瘍の発生率を増加させるか否かを調べた。80匹のオスと80匹のメスのラットを無作為に3つの群（擬似ばく露対照群、835.62 MHz FDMA信号ばく露群、847.74 MHz CDMA信号ばく露群）に割り当てた。ラットは2年間にわたり、1日4時間、週5日のばく露を受けた。動物の脳内の名目的な時間平均SARは、アンテナの時間平均出力１ワットあたり0.85±0.34 W / kg（平均±SD）であった。アンテナは、1.50±0.25 W（レンジ）の時間平均出力で駆動された。したがって、脳での名目の時間平均SARは1.3±0.5 W/ kgであった。この数字は、いくつかの脳の位置での平均であり、動物の体重、照射中の頭の位置の変化を考慮に入れた。すべての主要臓器を肉眼的および組織学的に検査し、各臓器の腫瘍の数、腫瘍の種類、および過形成の発生率を記録した。その結果、どの群の間にも、オスおよびメスのどちらにおいても、最終の体重、生存日数に有意差はなかった；いずれの臓器のいずれの腫瘍についても、ばく露群と擬似ばく露群の間に有意差はなかった、と報告している。

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研究目的（著者による）

To determine whether chronic exposure to radiofrequency radiation from cellular phones increased the incidence of spontaneous tumors in rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 835.62 MHz
ばく露時間: repeated daily exposure, 4 h/day, 5 days/week, over two years
  • 電力: 1.5 W average over time (± 0.25 W)
  • SAR: 1.3 W/kg average over time (brain) (± 0.5 W/kg)
ばく露2: 847.74 MHz
ばく露時間: repeated daily exposure, 4 h/day, 5 days/week, over two years
  • 電力: 1.5 W average over time (± 0.25 W)
  • SAR: 1.3 W/kg average over time (brain) (± 0.5 W/kg)

General information

Rats were randomly placed into three groups: Sham, FDMA exposure and CDMA exposure.

ばく露1

主たる特性
周波数 835.62 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 4 h/day, 5 days/week, over two years
Modulation
Modulation type cf. additional information
Additional information

FMCW, FDMA
ばく露装置
ばく露の発生源／構造
  • signal generator, standard telecom antennas
チャンバの詳細 The design of the exposure equipment has been described in [Moros et al., 1998]. Four chamberettes designed for the exposure of 40 rats each were equipped with four carousels (pseudo-random placement) and four central (standard telecom) antennas providing the EMF signal.
ばく露装置の詳細 A rat was placed in a clear acrylic restraint cylinder (four different sizes) and a retainer piece was secured to the back of the device. Ten restraint devices were then arranged symmetrically around the antenna on a carousel in the same (initially randomised) sequence every day. Any partially filled trays (due to died or killed rats) were completed with equivalent phantoms.
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力 1.5 W average over time 測定値 - ± 0.25 W
SAR 1.3 W/kg average over time 測定値 brain ± 0.5 W/kg
測定および計算の詳細

Functioning and stability of the equipment was verified and recorded daily and monitored regularly. Additional inspections were performed before, three times during and after the project.

ばく露2

主たる特性
周波数 847.74 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 4 h/day, 5 days/week, over two years
Modulation
Modulation type cf. additional information
Additional information

O-QPSK modulated, centered around 847.74 MHz, and spread over 1.288 MHz, CDMA
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
  • standard telecom antennas
パラメータ
測定量 値 種別 Method Mass 備考
電力 1.5 W average over time 測定値 - ± 0.25 W
SAR 1.3 W/kg average over time 測定値 brain ± 0.5 W/kg
測定および計算の詳細

The thermographic and thermometric dosimetry performed has been described in [Moros et al., 1999]. The time-averaged SAR in brain tissue measured thermometrically was 0.85 ± 0.34 W/kg per watt of net (time-averaged) input power to the antenna. Over the course of the study, the actual spot SAR in the brain (depending on spot location, head position and body weight) could vary from 0.5 W/kg to 2.5 W/kg.

Reference articles

  • Moros EG et al. (1999): [40匹の小型哺乳類に対する長期UHF同時照射に用いる小型遮蔽ばく露装置。第2部。ドシメトリ]
  • Moros EG et al. (1998): [小動物の長期間のUHF照射用のコンパクトなばく露装置：1電磁および環境面を考慮した設計]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 脳／腫瘍
  • all major organs (liver, kidney, heart, thymus, reproductive organs)
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

There were no significant differences among final survival days or body weights for either males or females in any group. No significant differences were found between treated and sham-exposed rats for any tumor in any organ. The authors conclude that chronic exposure to FDMA or CDMA radiofrequency radiation had no significant effect on the incidence of spontaneous tumors in rats.

研究の種別:

研究助成

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