この研究は、携帯電話が発生する電磁界と同等の電磁界(EMF)への2年間のばく露がラットの中枢神経系(CNS)の腫瘍発生を加速するか否かを調べた。妊娠18日目に、N-エチルニトロソウレア(ENU)の子宮内ばく露により脳腫瘍形成をイニシェートした。その後出生した合計500匹の仔ラットを5群に分けた(各群はオス50匹、メス50匹で構成された)。第1群は無処置対照群、第2群はENU単独処置群、第3-4群はENU + EMF(擬似ばく露および2つのばく露レベル)である。パーソナルデジタルセルラー(PDC)の1.439 GHz時分割多元接続(TDMA)信号の頭部へのばく露を5週齢から開始した。ばく露時間は1日90分、1週5日で104週間継続した。脳の平均比吸収率(SAR)は、低および高ばく露でそれぞれ0.67および2.0 W / kgであり、一方、全身平均SARは0.4 W / kg未満であった。結果として、5つの群の間に、体重、摂食量、生存率に差はなかった;EMFばく露群において、雌雄どちらでも、脳腫瘍および/または脊髄腫瘍の発生率または発生数に増加はなかった;さらに、腫瘍タイプの明確な変化は明らかでなかった、と報告している。
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To evaluate whether a 2 year exposure to an electromagnetic field equivalent to that generated by cellular phones can accelerate tumor development in the central nervous system of rats (brain tumorigenesis was initiated by an intrauterine exposure to N-ethylnitrosourea on gestational day 18).
ばく露 | パラメータ |
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ばく露1:
1.439 GHz
Modulation type:
pulsed
ばく露時間:
repeated daily exposure, 90 min/day, 5 days/week for 104 weeks
|
A total of 500 pups were divided into five groups: untreated control, ENU alone, ENU + EMF (two exposure levels + sham). N.B.: ENU treatment was done to their mothers on gestational day 18!
周波数 | 1.439 GHz |
---|---|
タイプ |
|
ばく露時間 | repeated daily exposure, 90 min/day, 5 days/week for 104 weeks |
ばく露の発生源/構造 |
|
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Distance between exposed object and exposure source | 30 mm |
チャンバの詳細 | The exposure box was 90 x 90 x 60 cm, the inside walls except for the ceiling being covered with electromagnetic absorber. Ten boxes were used simultaneously. |
ばく露装置の詳細 | Ten rats, fixed individually in plastic tubes (four different sizes), were set on a disk-shaped plate (65 cm in diameter) with their nose towards the center. A quarter-wavelength monopole antenna on the ceiling of the exposure box fitted in the center of the disk-shaped plate. The distance between the antenna and each rat nose was 30 mm and the distance between the ceiling and the rat back was 5 mm. |
Additional information | Plastic holders used were of four different sizes (inner diameter 4.0 cm, 4.7 cm, 5.5 cm, and 6.2 cm). If rats deceased, dummy rats were used to maintain symmetry and scheduled SAR in the exposure box. |
There were no differences between the groups in body weights, food consumption, and survival rates. No increase in the incidences per group of brain and/or spinal cord tumors, either in the males or females, was revealed in the exposed rats. Additionally, no clear changes in tumor types were evident.
In conclusion, under the present experimental conditions, 1.439 GHz electromagnetic field exposure to the heads of rats for a 2 year period was not demonstrated to accelerate or affect N-ethylnitrosourea initiated brain tumorigenesis
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