研究のタイプ: 医学／生物学の研究 (experimental study)

[パルス900 MHz電磁界にばく露されたEu-Pim1トランスジェニックマウスにおけるリンパ腫瘍] med./bio.

Lymphomas in Eµ-Pim1 transgenic mice exposed to pulsed 900 MHz electromagnetic fields

著者: Repacholi MH, Basten A, Gebski V, Noonan D, Finnie J, Harris AW
掲載誌: Radiat Res 1997; 147 (5): 631-640
RISフォーマットで参考文献をダウンロード

この研究は、中程度のリンパ腫自然発症傾向を持つように作成されたE mu-Pim1トランスジェニックマウスを用いて、デジタル移動通信で使用されるものと同様のパルス変調RF電磁界への長期ばく露がリンパ腫の発生率を増加させるか否かを調べた。100匹のメスのE mu-Pim1マウスに擬似ばく露を実施した。101匹の同様のマウスに、パルス化900MHz平面波電磁界（パルス繰り返し周波数217Hz、パルス幅0.6ms）の30分間ばく露を1日2回で、最大18ヶ月間実施した。入射電力密度は2.6-13W / m2、比吸収率は0.008-4.2W / kgの範囲であり、平均0.13-1.4W / kgであった。その結果、リンパ腫リスクは、ばく露群において対照群よりも有意に高かった（OR = 2.4、P = 0.006,95％CI = 1.3-4.5）；腫瘍発生率の増加には、濾胞性リンパ腫の寄与が最も大きかった、と報告している。

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的（著者による）

To determine whether long-term exposure to pulse-modulated radiofrequency fields similar to those used in digital mobile telecommunications would increase the incidence of lymphoma in Eµ-Pim1 transgenic mice (expressing an activated Pim1 oncogene in their lymphoid cells).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure for 30 min every 12 h for up to 18 months
  • 電力: 9.1 W mean
  • SAR: 4.2 W/kg average over mass (whole body) (0.008-4.2 W/kg for an individual mouse)
  • SAR: 1.4 W/kg average over mass (whole body) (0.13-1.4 W/kg for groups of five mice)
  • 電力密度: 13 W/m² maximum (2.6 - 13 W/m²)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 repeated daily exposure for 30 min every 12 h for up to 18 months
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Duty cycle 13 %
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源／構造
  • モノポール
  • RF generator
Distance between exposed object and exposure source 0.65 m
チャンバの詳細 The exposure room was 2.6 m long x 2.2 m wide x 2.45 high. Sham exposed mice were housed in a separate room, only 1.8 m wide. The rooms were lined with overlapping sheets of 1-mm aluminium (-40 dB at 900 MHz). Each room contained a vertical ground plane (2.5 m x 2.2 m), running parallel to the wall, with a quarter-wave monopole antenna at the center.
ばく露装置の詳細 Twenty Lucite® stands (15 cm x 30 cm) for mouse cages were mounted in a circular array perpendicular to the ground plane with their centers 0.65 m from the antenna. The mice were housed in groups of five in 18 x 15 x 30 cm filter-top transparent polycarbonate cages with a perforated glass lid.
Sham exposure A sham exposure was conducted.
Additional information To ensure equal average exposures, cages were moved clockwise to the next position twice weekly.
パラメータ
測定量 値 種別 Method Mass 備考
電力 9.1 W mean 測定値 - -
SAR 4.2 W/kg average over mass 測定値および計算値 whole body 0.008-4.2 W/kg for an individual mouse
SAR 1.4 W/kg average over mass 測定値および計算値 whole body 0.13-1.4 W/kg for groups of five mice
電力密度 13 W/m² maximum 測定値 - 2.6 - 13 W/m²
Additional parameter details

SAR values are maximal values; power flux density differs because of spatial field distribution.

測定および計算の詳細

The RF fields were measured using a broadband meter and an isotropic EF probe at each of the 20 mouse cage positions (distal end of the stand) and at 10 mm from the ground plane. Empirical calculations of the SAR values using spheroidal models for various weight groups of five mice were derived from the Radiofrequency Dosimetry Handbook [Durney et al., 1986]. The SAR for a single mouse was determined experimentally because the range of body weights and fat content of the mice did not fit the Handbook. The accuracy was estimated at ± 1.6 dB [Anderson and Joyner, 1995]. Measurements were made at 900 MHz CW in three phantoms consisting of thin plastic shells filled with two tissue-equivalent gels and representing small, medium and large mice of 26, 34 and 64 g, respectively. A miniature isotropic field probe with 1.5-mm dipoles was inserted at 0.25, 0.5 and 0.75 of the length into the phantoms placed on the bore-sight at 0.7 m (far field) from the aperture of a coaxial-to-waveguide adapter.

Reference articles

  • Anderson V et al. (1995): [アナログ式手持ち型携帯電話からの無線周波送信にばく露された人体模型頭部における比吸収率レベル測定]
  • Durney CH et al. (1986): [無線周波放射ドシメトリ・ハンドブック（第4版）]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 免疫系
  • 脳／腫瘍
  • thymus, lymph nodes, spleen, liver, lung, kidney, adrenal, bowel, urogenital system, eyes
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

Lymphoma risk was found to be significantly higher in the exposed mice than in the controls.

研究の種別:

研究助成

Replication studies

この論文に対するコメント

関連論文