この研究は、ウィスターラットにマイクロ波の長期ばく露(2.856GHz;平均電力密度5、10、20、30mW/cm2;6分間ばく露を週3回;6週間)を与え、認知およびセロトニン作動性受容体への影響を調べた。その結果、空間の学習と記憶の機能、海馬の形態学的構造、脳電図、神経伝達物質に変化が観察された;トリプトファン加水分解酵素1(Tph1)およびモノアミン酸化酵素(MAO)が検出された;5-HT 1A、2A、2Cを含むセロトニン受容体の発現が見られた,と報告している。
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The effects of a chronic exposure of rats to a 2.856 GHz electromagnetic field on memory, serotonin system and the content of some neurotransmitters in the brain should be investigated.
75 rats were divided into the following 5 groups (n=15 each): Exposure to a electromagnetic field with a power of 1) 5 mW/cm2, 2) 10 mW/cm2, 3) 20 mW/cm2 and 4) 30 mW/cm2 or 5) sham exposure. The animals were examined at different time points up to 2 month after exposure.
ばく露 | パラメータ |
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ばく露1:
2.856 GHz
ばく露時間:
continuous for 6 min. 3 times/week for 6 weeks.
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ばく露2:
2.856 GHz
ばく露時間:
continuous for 6 min. 3 times/week for 6 weeks.
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ばく露3:
2.856 GHz
ばく露時間:
continuous for 6 min. 3 times/week for 6 weeks.
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|
ばく露4:
2.856 GHz
ばく露時間:
continuous for 6 min. 3 times/week for 6 weeks.
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周波数 | 2.856 GHz |
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タイプ |
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波形 |
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ばく露時間 | continuous for 6 min. 3 times/week for 6 weeks. |
ばく露の発生源/構造 |
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測定量 | 値 | 種別 | Method | Mass | 備考 |
---|---|---|---|---|---|
電力密度 | 10 mW/cm² | mean | 測定値 | - | - |
周波数 | 2.856 GHz |
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タイプ |
|
波形 |
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ばく露時間 | continuous for 6 min. 3 times/week for 6 weeks. |
ばく露の発生源/構造 |
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測定量 | 値 | 種別 | Method | Mass | 備考 |
---|---|---|---|---|---|
電力密度 | 20 mW/cm² | mean | 測定値 | - | - |
周波数 | 2.856 GHz |
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タイプ |
|
波形 |
|
ばく露時間 | continuous for 6 min. 3 times/week for 6 weeks. |
ばく露の発生源/構造 |
|
---|
測定量 | 値 | 種別 | Method | Mass | 備考 |
---|---|---|---|---|---|
電力密度 | 30 mW/cm² | mean | 測定値 | - | - |
The spatial memory was significantly impaired in all exposure groups compared to the sham exposure. In the EEG, significant differences were found between all exposure groups and sham exposure (changes in amplitude, frequency and delta wave power).
Morphological analysis showed karyopyknosis and nucleus deformations in the hippocampus and neuronal degradation in the cortex in all exposure groups but not in the sham exposure. The most severe effects were detected in group 4 (30 mW/cm2).
The content of several neurotransmitters was punctually significantly reduced or increased in different groups and at different time points after exposure compared to the sham exposure without any distinct trend. The monoamine oxidase enzyme activity was significantly reduced 28 days and 2 months after exposure in group 4 compared to sham exposure. The expression rates of 5-HT1AR and 5-HT2CR were significantly increased in group 4 compared to sham exposure at different time points.
The authors conclude that a chronic exposure of rats to a 2.856 GHz electromagnetic field could impair the memory and alter the serotonin system and the content of some neurotransmitters in the brain.
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