この研究は、フィッシャ−ラットの脳のモノアミン神経伝達物質、それらを制御する重要な酵素の遺伝子発現に対する低強度のマイクロ波放射の影響を調べた。マイクロ波（900MHzまたは1800MHz、SARは両方とも約0.6mW/kg）のばく露を30日間（1日2時間、週5日）行った。ばく露終了後に脳の海馬のドーパミン（DA）、ノルエピネフリン（NE）、エピネフリン（E）セロトニン（5-HT）のレベル、チロシン水酸化酵素（TH）およびトリプトファン水酸化酵素（TPH1および2）のmRNA発現を測定した。その結果、対照（擬似ばく露）群に比べ、マイクロ波ばく露群では、海馬のDA、NE、E、5-HTレベルが有意に低下した；同じく、TH、TPH1および2のmRNA発現が有意に低下した、と報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
To investigate the effects of exposure to low-intensity microwaves on monoamine neurotransmitter levels and their key regulating enzymes in the brain of rats.
Three groups of rats were examined (n=6 per group): 1.) sham exposure, 2.) 900 MHz microwave exposure and 3.) 1800 MHz microwave exposure.
The enzyme tyrosine hydroxylase catalyzes the reaction to form a precursor for dopamine, which, in turn, is a precursor for the neurotransmitters norepinephrine and epinephrine. Tryptophan hydroxylase is an enzyme involved in the synthesis of the neurotransmitter serotonin.
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 2 hours per day, 5 days per week |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 100 cm |
| チャンバの詳細 | rats were restrained in closed boxes (L: 30 cm x B: 15 cm x H: 20 cm), provided with holes of 1 cm diameter for ventilation and were kept at a distance of 100 cm from the source |
| ばく露装置の詳細 | GTEM cell was a pyramidal tapered, dual-terminated section (L: 220 cm x B: 120 cm x H: 80 cm); microwave source consisted of a signal generator operating at a frequency range of 9 kHz to 3.2 GHz, an amplifier, a DC regulator and a power meter; microwave chamber was lined with absorbers to minimize reflections |
| Sham exposure | A sham exposure was conducted. |
The levels of the neurotransmitters dopamine, norepinephrine, epinephrine were significantly decreased in exposed rats (900 MHz and 1800 MHz) compared to sham exposed rats. The level of serotonin was also decreased in the exposed groups when compared to the sham exposure, but only significantly in the group exposed to the 1800 MHz microwaves. Additionally, in both exposure groups the gene expression of the enzymes tyrosine hydroxylase and tryptophan hydroxylase was significantly decreased in comparison to the sham exposed animals.
The authors conclude that exposure to low-intensity microwaves influences monoamine neurotransmitter levels and their key regulating enzymes in the brain of rats.
このウェブサイトはクッキー（Cookies）を使って、最善のブラウジングエクスペリエンスを提供しています。あなたがこのウェブサイトを継続して使用することで、私たちがクッキーを使用することを許可することになります。
