この研究は、4週齢雄ウィスターラットに無線周波電磁放射(RF-EMR;900MHz;SAR 1.15W/kg、電力密度ピーク値146.60μW/cm2)を1日1時間、28日間のばく露を与え、その後、空間認知の行動テスト(モーリスの水迷路テスト)および海馬の組織検査を実施した。その結果、ばく露群では、前進的な学習能力が低下した;また、訓練の24時間後に行った記憶保持テストで小さな空間記憶障害がみられた;海馬に構造的変化がみられた、などの所見を報告している。
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The effects of a chronic exposure of rats to a 900 MHz electromagnetic field on spatial memory and the neural structure in the hippocampus should be investigated.
Rats were divided into the following groups: 1) exposure to the electromagnetic field (n=24), 2) sham exposure (n=24) and 3) cage control (n=24).
周波数 | 900 MHz |
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タイプ |
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ばく露時間 | continuous for 1 h/day for 28 days |
ばく露の発生源/構造 |
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チャンバの詳細 | polypropylene cages (41 Œ 28 Œ 14 cm) |
ばく露装置の詳細 | an activated mobile phone (silent mode, giving unattended calls (50 calls/h) with the help of an auto dialer) was inserted in a wire mesh cage (12 Œ 7 Œ 7 cm) and placed at the center of the animal cage (n=3 rats per cage) |
Sham exposure | A sham exposure was conducted. |
There were no significant differences in the body weight between the groups.
Learning and the spatial memory were significantly deteriorated in rats exposed to the electromagnetic field compared to cage control and sham exposure groups.
No cellular aggregates were found in any group, but neuronal cell viability was significantly decreased in exposed rats compared to cage control and sham exposure rats. Moreover, pyramidal cells of exposed rats showed significantly less dendritic arborization compared to the cage control group.
The authors conclude that chronic exposure of rats to a 900 MHz electromagnetic field could impair spatial memory and the neural structure in the hippocampus and they propose a causal relationship.
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