この研究は、ラットに、携帯電話基地局(実験室のある建物に設置された)からの電磁放射(EMR:900 MHz、アンテナとラットのケージとの距離は8m、電力密度測定値は0.5 mW/ cm2)への慢性ばく露(24時間/日、8週間)を与え、血液パラメータへの影響を調べ、その影響に対するゴマ油の保護作用も合わせて調べた。雄アルビノラットを、対照群と3つのばく露群(各n = 8)に分け、3つのばく露群にはそれぞれ、ゴマ油を0、1.5、3 ml経口摂取させた(週に3回)。慢性ばく露終了後に、血漿中のグルタチオンレダクターゼ(GSH-Rx)、スーパーオキシドジスムターゼ(SOD)、カタラーゼ(CAT)、総テストステロンおよび脂質プロファイル(総コレステロール(Tch)、トリグリセリド(TG)、低密度リポタンパク質コレステロール(LDL-c)および高密度リポタンパク質コレステロール(HDL-c))を測定した。その結果、3つのばく露群で、対照群に比べ、TGとテストテロンが有意に上昇し、かつゴマ油の摂取量依存的に有意に上昇した;SODおよびCAT活性は、対照群に比べ、EMRのみのばく露群では有意に低下したが、EMR +ゴマ油摂取群では油の摂取量依存的に有意に上昇した;3mlのゴマ油摂取群でのみ、総コレステロールの顕著な低下、GSH-Rxの有意な上昇が見られた、と報告している。
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The effects of exposure of rats to a 900 MHz electromagnetic field on blood parameters and the possible protective role of sesame oil (antioxidant) against oxidative stress should be investigated.
Rats were divided into the following groups (n=8 each): 1) exposure to the electromagnetic field, 2) exposure and administration of 1.5 ml sesame oil, 3) exposure and administration of 3 ml sesame oil, 4) control group. Groups 2 and 3 received the sesame oil orally three times a week.
ばく露 | パラメータ |
---|---|
ばく露1:
900 MHz
ばく露時間:
continuous for 24 h/day for 8 weeks
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|
周波数 | 900 MHz |
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タイプ |
|
ばく露時間 | continuous for 24 h/day for 8 weeks |
ばく露の発生源/構造 |
|
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Distance between exposed object and exposure source | 8 m |
チャンバの詳細 | plastic cages |
ばく露装置の詳細 | base station was constructed on the roof of a building |
測定量 | 値 | 種別 | Method | Mass | 備考 |
---|---|---|---|---|---|
電力密度 | 0.5 mW/cm² | - | 測定値 | - | - |
The level of testosterone was significantly increased in all exposure groups (groups 1-3) and the level of triglycerides was significantly increased in both exposure groups with sesame oil (groups 2 and 3) compared to the control group.
The superoxide dismutase and catalase enzyme activities were significantly reduced in exposed rats without sesame oil (group 1) and they were significantly increased in exposed rats with sesame oil (partly in group 2, consistently in group 3) compared to the control group.
The total cholesterol level was significantly reduced and the glutathione reductase enzyme activity was significantly increased in group 3 compared to the control group.
HDL and LDL cholesterol showed contrary trends: HDL cholesterol was significantly reduced in group 1 compared to the control group and groups 2 and 3 showed significantly increased values compared to group 1. LDL cholesterol was significantly increased in group 1 compared to the control group and groups 2 and 3 showed significantly reduced values compared to group 1.
The authors conclude that exposure of rats to a 900 MHz electromagnetic field might influence blood parameters and induce oxidative stress and that sesame oil as an antioxidant might attenuate these effects.
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