この研究は、成獣のSD雄ラットの生殖系に対する無線周波電磁界（RF-EMF：900MHz）の影響を、FSH、LH、inhibin B、activin B、プロラクチン、テストステロンの血中レベルを測定することにより評価した。RF-EMFばく露にはダイポールアンテナを用い、ラットが自由行動するケージ内の電力密度は86 mW/cm2（22.8-146.8 mW/cm2）と測定され、ラットの全身平均SARは0.19-1.22 W/kgと計算された。20匹のラットは5匹ずつの4群に分けた。1日のばく露時間が1、2、4時間群と対照群（疑似ばく露と称している）である。ばく露は30日間継続した。ばく露前、ばく露15日後、30日後に上記のホルモンレベルを測定した。30日後の測定結果では、4時間ばく露群のFSH、LHレベルが疑似ばく露群より有意に高かった；また、4時間ばく露群では疑似ばく露群および1時間ばく露群に比べ、activin Bとプロラクチンの増加およびinhibin Bの減少が有意であった；さらに、4時間ばく露群では1および2時間ばく露群に比べ、テストステロンレベルが有意に減少した、と報告している。
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To investigate the effects of exposure to radiofrequency fields on reproductive hormone levels in the blood serum of male rats.
Four groups of rats were examined (n=5 per group): 1.) sham exposure, 2.) 1 h/day exposure, 3.) 2 h/day exposure and 4.) 4 h/day exposure. Rats were exposed for 30 days. Blood samples were taken before, during (after 15 days) and after the exposure period.
Activin B and inhibin B are proteins which can regulate the follicle stimulating hormone secretion at the pituitary.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
900 MHz
Modulation type:
CW
ばく露時間:
1 h/day for 30 consecutive days
|
|
|
ばく露2:
900 MHz
ばく露時間:
2 h/day for 30 consecutive days
|
|
|
ばく露3:
900 MHz
ばく露時間:
4 h/day for 30 consecutive days
|
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 1 h/day for 30 consecutive days |
| Modulation type | CW |
|---|
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | five freely moving rats were kept in one transparent polycarbonate cage without metallic parts (42 cm x 26.5 cm x 15 cm) |
| ばく露装置の詳細 | signal generator with a 12 cm dipole antenna which diffused a 900 MHz continuous wave in the spherical mode; output was monitored by a spectrum analyzer to ensure the correct forward power for the exposed animals; temperature was monitored continuously and was 23 ± 1°C |
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 2 h/day for 30 consecutive days |
| ばく露の発生源／構造 |
|
|---|
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | 4 h/day for 30 consecutive days |
| ばく露の発生源／構造 |
|
|---|
After 30 days of 4 hours daily exposure, the levels of the follicle stimulating hormone and the luteinizing hormone were significantly increased compared to the sham exposure. Additionally after 30 days, the levels of activin B and prolactin were significantly increased in the group exposed for four hours daily in comparison to the sham exposure and to the group exposed for 1 hour daily, while the level of inhibin B was significantly decreased. The serum level of testosterone was significantly decreased in the 4 hours exposed group after 30 days when compared to the 1 hour and 2 hours exposure group.
The authors conclude that exposure to radiofrequency fields can disturb reproductive hormone levels in the serum of rats.
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